Upgrade of a 500 MHz NMR Spectrometer

化学研究仪器和设施项目的这一奖项将帮助加州大学圣巴巴拉分校的化学系升级现有的500 MHz光谱仪，用于研究。将支持的研究活动包括：开发用于DNA和RNA中二烷基-磷酸键水解的序列特定催化剂的研究，含血红素酶的模拟化合物的合成和研究，由海洋细菌产生的铁载体和其他含金属化合物的表征，具有高治疗潜力的新材料的合成，以及蛋白质和其他具有生物重要性的结构的结构和动力学的阐明。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物和催化等领域以及生物学中都是有用的。

This award from the Chemistry Research Instrumentation and Facilities Program will help the Department of Chemistry at the University of California--Santa Barbara acquire an upgrade of an existing 500 MHz spectrometer which will be used in research. The research activity to be supported include: studies of the development of sequence specific catalysts for the hydrolysis of dialkyl-phosphate linkages in DNA and RNA, the synthesis and study of mimics of heme-containing enzymes, the characterization of siderophores and other metal- containing compounds produced by marine bacteria, synthesis of new materials that have high therapeutic potential, and the elucidation of the structure and dynamics of proteins and other structures of biological importance. Nuclear Magnetic Resonance (NMR) Spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.