Acquisition of a 400 MHz NMR Spectrometer

请拨资金为密西西比大学化学系购买一台400兆赫核磁共振波谱仪。这台光谱仪的收购将极大地加强该系在有机、无机、生物化学和生物物理学领域正在进行的研究计划。核心用户群体需要一台比化学系目前可用的更先进的脉冲技术的高场NRM光谱仪，以扩大我们对蛋白质、寡核苷酸和相关物种等大分子以及结构复杂的“小”有机分子的研究。五个核心用途的具体应用包括(1)配体-寡核苷酸相互作用的研究，(2)利用构象受限氨基酸类似物的多肽结构，(3)用于形成自组装单分子膜的烷基硫醇的结构分析，(4)有机供体-受体分子的结构分析，(5)生物活性天然产物的结构鉴定。

Funds are requested for the purchase of a 400 MHz NMR spectrometer for the Department of Chemistry at the University of Mississippi. Acquisition of this spectrometer will greatly enhance ongoing research programs in areas of organic, inorganic, biochemistry, and biophysics within this department. The core user group requires a higher-field NRM spectrometer with more advanced pulse techniques than is currently available in the Department of Chemistry to extend our studies involving large molecules such as proteins, oligonucleotides and related species as well as structurally complex "small" organic molecules. Specific applications of five core users include (1) the study of ligand- oligonucleotide interactions, (2) polypeptide structures using conformationally contrained amino acid analogs, (3) structual analysis of alkane thiols used to form self- assembled monolayers, (4) structural analyses of organic donor-acceptor molecules, (5) structural elucidation of biologically active natural products.