Acquisition of a 400 MHz NMR Spectrometer

请求经费用于为密西西比大学化学系购买一台400兆赫核磁共振光谱仪。该光谱仪的获得将极大地加强该部门在有机、无机、生物化学和生物物理学领域的研究项目。核心用户群需要比化学系现有的更高场NRM光谱仪，具有更先进的脉冲技术，以扩展我们对大分子（如蛋白质、寡核苷酸和相关物种）以及结构复杂的“小”有机分子的研究。五个核心用户的具体应用包括(1)配体-寡核苷酸相互作用的研究，(2)利用含有构象的氨基酸类似物进行多肽结构的研究，(3)用于形成自组装单层的烷烃硫醇的结构分析，(4)有机供体-受体分子的结构分析，(5)生物活性天然产物的结构阐明。

Funds are requested for the purchase of a 400 MHz NMR spectrometer for the Department of Chemistry at the University of Mississippi. Acquisition of this spectrometer will greatly enhance ongoing research programs in areas of organic, inorganic, biochemistry, and biophysics within this department. The core user group requires a higher-field NRM spectrometer with more advanced pulse techniques than is currently available in the Department of Chemistry to extend our studies involving large molecules such as proteins, oligonucleotides and related species as well as structurally complex "small" organic molecules. Specific applications of five core users include (1) the study of ligand- oligonucleotide interactions, (2) polypeptide structures using conformationally contrained amino acid analogs, (3) structual analysis of alkane thiols used to form self- assembled monolayers, (4) structural analyses of organic donor-acceptor molecules, (5) structural elucidation of biologically active natural products.