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Life at the nanometre scale: imaging immunological synapses with a novel super-resolution fluorescence microscope

Life at the nanometre scale: imaging immunological synapses with a novel super-resolution fluorescence microscope
纳米尺度的生命:用新型超分辨率荧光显微镜对免疫突触进行成像
批准号:
LP100200021
负责人:
Prof Katharina Gaus
金额:
$30.06万
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-03-18 至 2014-12-31

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中文摘要
翻译
该项目旨在对活化白细胞中的单个蛋白质进行成像,以了解淋巴细胞如何参与免疫反应。问题是目前的成像方式要么缺乏分辨率,要么不适合活细胞和三维(3D)成像。该项目将与该项目的行业合作伙伴卡尔蔡司微成像公司(Carl Zeiss MicroImaging)合作,建立并应用一种新型显微镜,该显微镜能够在3D中观察单个蛋白质和活细胞。这项技术将在真正的分子尺度上提供信号和淋巴细胞功能的见解。
英文摘要
This project aims to image individual proteins in activated white blood cells in order to understand how lymphocytes participate in an immune response. The problem is that current imaging modalities either lack resolution or are unsuitable for live cell and three-dimensional (3D) imaging. With the project’s industry partner, Carl Zeiss MicroImaging, the project will build and apply a novel microscope that is capable of visualising single proteins in 3D and live cells. This technology will provide insights into signalling and lymphocyte function on a true molecular scale.
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T cell receptor (TCR) singalling efficiency
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 负责人:
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Confocal and single molecule microscopes for systems microscopy
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 负责人:
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DNA nanotechnology for controlled antigen presentation to T cells
  • 批准号:
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
    2017
  • 负责人:
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  • 依托单位:
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  • 项目类别:
    Discovery Projects
  • 资助金额:
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  • 财政年份:
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  • 负责人:
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  • 依托单位:
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