New Synthetic Organometallic Chemistry

拟议的研究涉及开发新的合成方法，涉及在催化浓度下使用的有机铜中间体。反应将包括1)弗莱明的硅基铜酸盐化学，2)使用稀土和其他稀土助催化剂，3)功能化的锌和锆试剂与三氟乙烯基和芳基三氟酸盐的烷基化反应，以及4)使用氢化铜络合物1，4-还原α，β-不饱和羰基化合物。拉曼光谱、红外光谱和电喷雾质谱仪将用于测定溶液中有机铜的组成和结构。通过这一续展奖项，有机和高分子化学项目为加州大学圣巴巴拉分校化学系的Bruce LipShuz博士的研究提供持续支持。这项研究包括开发合成方法，以在温和的条件下制备高选择性的有机化合物。这项工作将在有机合成和反应中间体的光谱鉴定方面为研究生和博士后研究员提供有价值的培训。

The proposed research involves the development of new synthetic methods involving organocopper intermediates used at catalytic concentrations. Reactions will include 1) Fleming's silyl cuprate chemistry, 2)the use of lanthanide and other rare earth cocatalysts, 3) alkylations of functionalized Zn and Zr reagents with vinyl and aryl triflates, and 4)1,4-reductions of alpha,beta-unsaturated carbonyl compounds using copper hydride complexes. Raman and IR spectroscopy, and electrospray mass spectrometry, will be used to determine organocuprate compositions and structures in solution. With this renewal award, the Organic and Macromolecular Chemistry Program provides continuing support for the research of Dr. Bruce Lipshutz of the Department of Chemistry at the University of California at Santa Barbara. The research involves the developmentof synthetic methods for preparing organic compounds under mild conditions and with high selectivities. The work will provide valuable training to graduate students and post-doctoral fellows in organic synthesis and the spectroscopic identification of reaction intermediates.