Oxidations by Electrophilic Multiply Bonded Ligands

该奖项在无机，生物无机和有机化学计划支持研究金属介导的氧化反应博士詹姆斯M。华盛顿大学化学系的Mayer。 当亲核试剂，无论是从其他网站的配合物或从其他分子，与亲电氧，氮，或亚氨基配体反应，金属被正式还原，亲核试剂被氧化。 在这些情况下，氧化位点是金属和配体之间的多重键。 本研究的目的是确定如何通过金属中心的变化来调节配体的亲电性。 碳负离子，硼烷和烯烃的氧化将被研究和反应机理的确定。 将制备新的氧化剂，包括锇（VI）-和锇（VIII）-氧代配合物，过渡金属对有机化合物的选择性氧化是生产许多商品化学品，包括药品的关键步骤，在废物处理中也越来越重要。 需要了解关键反应步骤来改进现有技术。 本研究的目的是阐明一类这样的金属介导的氧化反应的化学。 各级学生将参与研究，并将学习许多不同的仪器方法和实用的实验室技能。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research on metal-mediated oxidation reactions by Dr. James M. Mayer of the Chemistry Department, University of Washington. When nucleophiles, either from other sites in the complex or from other molecules, react with electrophilic oxo, nitrido, or imido ligands, the metal is formally reduced and the nucleophile is oxidized. In these cases, the site of oxidation is the multiple bond between the metal and the ligand. The goal of this research is to determine how the ligand electrophilicity can be tuned by changes at the metal center. Oxidations of carbanions, boranes and alkenes will be studied and the reaction mechanisms determined. New oxidants will be prepared, including osmium (VI)- and osmium (VIII)-oxo complexes.Selective oxidation of organic compounds by transition metals is a critical step in the production of many commodity chemicals, including pharmaceuticals, and is gaining importance in waste treatment. Understanding key reaction steps is needed to improve present technology. This research is aimed at elucidating the chemistry of one class of such metal-mediated oxidation reactions. Students at all levels will be involved in the research and will learn many different instrumental methods and practical laboratory skills.