Mannosyl transfer processes in leishmania and mycobacteria

人类疾病利什曼病和肺结核是由传染性微生物引起的。我们将瞄准含有代谢物的寄生虫特异性甘露糖的生物合成和降解途径，这些代谢物在这些病原体引起疾病的能力中发挥重要作用。我们将开发新的方法来研究这些途径，并将合成新的底物和抑制剂，这将允许开发抗结核和抗利什曼药物。该项目将有助于提高我国在新兴化学生物学领域的竞争力。

The human diseases leishmaniasis and tuberculosis are caused by infectious microorganisms. We will target pathways to the biosynthesis and degradation of parasite-specific mannose containing metabolites that play essential roles in the ability of these pathogens to cause disease. We will develop new ways to study these pathways, and will synthesize novel substrates and inhibitors that will allow the development of antituberculosis and antileishmanial drugs. This project will contribute to our national competitiveness in the newly emerging area of chemical biology.