MRI: Upgrade of a 500 MHz Nuclear Magnetic Resonance Spectrometer

有了化学研究仪器和设施(CRIF)和重大研究仪器项目的这一奖项，堪萨斯大学化学系将获得500 MHz核磁共振光谱仪的升级。该设备将加强以下方面的研究：血红素蛋白模型的结构研究；研究多肽螺旋和片状成核的合成系统的开发；DNA聚合酶光亲和探针的开发和表征；不对称P-和S有机化合物的合成；疏水驱动的多肽聚集的研究；腐植酸和富里酸对金属络合和聚集体形成的表征；以及通过结构研究开发提高多肽类药物生物利用度的化学策略。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) and Major Research Instrumentation Programs, the Department of Chemistry at the University of Kansas will acquire an upgrade of a 500 MHz NMR Spectrometer. This equipment will enhance research on structural studies of hemoprotein models; the development of synthetic systems to study nucleation of peptide helices and sheets; the development and characterization of DNA polymerase photoaffinity probes; synthesis of asymmetric P- and S-containing organic compounds; the study of hydrophobically-driven peptide aggregation; characterization of metal complexation and aggregate formation by humic and fulvic acids; and the development of chemical strategies for improving bioavailability of peptidomimetics through structural studies. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.