NIRT: Highly Integrated Optical Nanoparticle-Based Sensing Systems Based on Nanoparticle Synthesis, Assembly, and Integration

NIRT：高度集成的光学纳米传感系统项目摘要本NIRT的重点是通过利用纳米材料的传感器系统的性能和便携性的显着改善。这种综合方法依赖于由来自杜克大学、韦恩州立大学和威斯康星大学麦迪逊分校的化学家、电气工程师、生物医学工程师、材料科学家和化学工程师组成的团队。拟议活动的智力价值来自科学和工程探索和发现，这些探索和发现是设计和制造一个芯片上系统传感系统的基础，该系统利用纳米结构材料作为多光谱发射器和强大的目标探针。纳米颗粒对于传感越来越重要，并提供了一系列光学模式。来自纳米颗粒的光学信号通常比散装材料显著增强，从而允许整个传感系统的小型化。纳米粒子将用于不同的功能：作为光发射器，使传感和分子信标，以增强传感过程中产生的信号。 将研究这种集成方法的有效性，使用这些传感/检测介质来识别标记的分子和内源性荧光靶标。 该传感器平台利用了新的纳米结构传感和发射介质、光学发射器结构、新的材料集成手段，并展示了从片上集成获得的性能改进。该项目的更广泛的影响来自团队的学科和人口的多样性，以及通过与多样性计划的联系将本科生纳入项目。将产生教育文章和课程材料，例如教育期刊上的文章，这些文章使用研究成果和当地专业知识来传达传感方面的新概念。

NIRT: Highly Integrated Optical Nanoparticle-Based Sensing Systems Project SummaryThis NIRT focuses on significant improvements in the performance and portability of sensor systems through the exploitation of nanoscale materials. This comprehensive approach relies on the team composed of chemists, electrical engineers, biomedical engineers, materials scientists and chemical engineers from Duke University, Wayne State University and the University of Wisconsin-Madison. The intellectual merit of the proposed activity results from the scientific and engineering exploration and discovery underlying the design and fabrication of a system-on-a-chip sensing system exploiting nanostructured materials as both multi-spectral emitters and robust targeted probes. Nanoparticles are increasingly important for sensing and offer a range of optical modalities. Optical signals from nanoparticles are often significantly enhanced over bulk materials allowing for miniaturization of the entire sensing system. Nanoparticles will be used in different functions: as light emitters to enable sensing and as molecular beacons to enhance signals generated during sensing. The efficacy of this integrated approach will be studied the use of these sensing\detection media to recognize tagged molecular and endogenous fluorescence targets. The sensor platform exploits new nanostructure sensing and emitting media, optical emitter structures, new means of materials integration, and demonstrates the improvements in performance gained from on-chip integration. The broader impacts of this project derive from the diversity, both disciplinary and demographic, of the team, and the inclusion of undergraduate students in the project through linkages with diversity programs. Educational articles and curricular materials will be generated such as articles in educational journals that use research results and local expertise to communicate new concepts in sensing.