Acquisition of a 500-MHz NMR Spectrometer

在主要研究仪器(MRI)收购计划的支持下，印第安纳大学-普渡大学印第安纳波利斯分校(IUPUI)的化学和化学生物学系将获得一台500 MHz核磁共振光谱仪。该光谱仪将用于各种研究，包括天然和非天然产品、生物医学应用的先进聚合物、电子转移和自旋交叉反应、蛋白质酪氨酸磷酸酶、与DNA结合的金属多肽、多肽类药物的合成、立体选择性的硼烷基化研究、鞘磷脂的结构表征以及聚乙炔的生物合成途径。核磁共振波谱是化学家用于阐明分子结构的最广泛使用的工具。它被用来识别未知物质，并提供有关分子中原子的排列和连接性的信息。获得的动力学信息提供了对分子运动的洞察。该奖项将为国际理工学院(IUPUI)的教职员工和学生提供基本的分析能力。计划为学生用户创建和实施核磁共振认证计划，以提高新仪器的教育价值。

With support from the Major Research Instrumentation (MRI) Acquisition Program, the Department of Chemistry and Chemical Biology at Indiana University-Purdue University at Indianapolis (IUPUI) will acquire a 500 MHz NMR spectrometer. The spectrometer will be used in various research investigations involving natural and non-natural products, advanced polymers for biomedical applications, electron transfer and spin-crossover reactions, protein tyrosine phosphatases, metallopeptides that bind to DNA, synthesis of peptidomimetics, stereoselective boron alkylation studies, structural characterization of sphingolipids, and biosynthetic pathways to polyacetylenes. Nuclear Magnetic Resonance (NMR) Spectroscopy is the most widely used tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances and to provide information on the arrangement and connectivity of atoms in molecules. Dynamical information is obtained providing insight on the motions of molecules. This award will provide essential analytical capabilities to faculty and students at (IUPUI). Creation and implementation of a NMR certification program for student users is planned to enhance the educational value of the new instrument.