Asymmetric Catalysis in Main Group Chemistry with Chiral Lewis Bases

本项目的主要目标是（1）发明在手性刘易斯碱活化的刘易斯酸催化下的烯氧基硅烷亲核试剂和异腈的催化的、对映选择性的反应，（2）将亲电特性的亲核活化的概念扩展到周期表中的其他元素，如锡、镓和铟，（3）手性刘易斯碱催化反应的结构和机理研究。 与这些目标相关联的是各种刘易斯碱与硅卤化物的络合物的固态和溶液态结构的基本机理研究以及羟醛和环氧化物开环反应的全动力学分析。 有了这个奖项，有机和高分子化学计划是支持教授斯科特E。丹麦，伊利诺伊大学香槟分校化学系。 Scott E.丹麦的研究工作围绕着发现、开发和利用手性刘易斯碱催化的新型不对称反应。 鉴于在化学企业的许多领域中对单一对映体物质的强调，提供这种物质的新的通用和选择性方法目前受到极大关注。

The primary objectives of this project are (1) invention of catalytic, enantioselective reactions of enoxysilane nucleophiles and isonitriles under catalysis by chiral Lewis base activated Lewis acids, (2) the extension of the concept of nucleophilic activation of electrophilic character to other elements in the periodic table such as tin, gallium, and indium, and (3) structural and mechanistic investigation of the reactions catalyzed by chiral Lewis bases. Allied with those objectives are the fundamental mechanistic investigations of the solid and solution state structures of complexes of various Lewis bases with silyl halides and the full kinetic analysis of aldol and epoxide opening reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Scott E. Denmark, of the Department of Chemistry at University of Illinois at Urbana-Champaign. Professor Scott E. Denmark's research efforts revolve around the discovery, development, and exploitation of novel, asymmetric reactions catalyzed by chiral Lewis bases. Given the emphasis on single enantiomer substances in many areas of the chemical enterprise, new general and selective processes that provide such materials are of great current interest.