MRI: Acquisition of a 500 MHz NMR Spectrometer at Jackson State University

凭借重大研究仪器计划(MRI)的这一奖项，来自杰克逊州立大学的余洪涛及其同事Kenneth Lee和Eric Noe将获得一台500 MHz核磁共振(核磁共振)光谱仪。所要求的仪器将用于升级杰克逊州立大学的核磁共振核心设施。新的光谱仪将特别适用于小批量生产的样品的高灵敏度、高分辨率的结构分析，如代谢物或光产物、低温研究和复杂的天然产物衍生物。将利用该光谱仪的具体研究项目包括：(1)微克量光或化学降解的化学物质、光诱导的DNA加合物和代谢物的结构表征；(2)相对复杂的天然产物及其类似物的表征；(4)用于阴离子识别的有机金属化合物和大分子的表征和动力学研究；(4)有机化合物的低温构象研究；(5)合成有机化合物和中间体的结构指认。核磁共振波谱是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学和生物化学产生影响。

With this award from the Major Research Instrumentation program (MRI), Hongtao Yu and colleagues Kenneth Lee and Eric Noe from Jackson State University will acquire a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The requested instrument will be used to upgrade the NMR Core Facility at Jackson State University. The new spectrometer will be especially suited for high sensitivity, higher resolution structural analysis of samples produced in small quantities such as metabolites or photoproducts, low temperature studies, and complex natural product derivatives. Specific research projects that will utilize this spectrometer are: (1) structure characterization of microgram amounts of chemicals from light or chemical degradation, light-induced DNA adducts, and metabolites; (2) characterization of relatively complex natural products and their analogues; (4) characterization and kinetic study of organometallic compounds and macromolecules for anion recognition; (4) low temperature conformational studies of organic compounds; (5) structural assignment for synthetic organic compounds and intermediates.Nuclear Magnetic Resonance spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry.