Acquisition of a Liquid Chromatograph/Mass Spectrometer

罗彻斯特大学的Robert K. Boeckman Jr.教授和Joseph P. Dinnocenzo教授获得了化学研究仪器和设施：部门多用户仪器计划（CRIF:MU）的这份合同，他们将获得一台高灵敏度的离子阱质谱仪，配备了现代液相色谱仪（LC-MS），以及电喷雾（ES）和大气压化学电离（APCI）离子源。它将被用于各种研究项目，包括研究：a) 14族阳离子自由基中间体的化学；B)设计和开发新的化学酶和化学生物合成方法；C)较重铂族和铸币族元素配合物的化学性质；D)天然产物合成新反应的发现；E)具有催化活性的不饱和反应性铁配合物的性质；f)使用同位素标记的过渡金属配合物激活C-H、C-S、C-CN和C-F键。质谱法（MS）是通过测量样品中分子组分电离后经质谱仪检测后的质量，来鉴定样品的化学成分并确定其纯度的方法。色谱法是一种先于质谱分析的分离技术。它将混合物分离成几种化学成分，然后用质谱仪进行分析。这些是广泛使用的分析技术，用于鉴定和定量样品的化学成分。此次收购将通过系里的研究项目和本科生化学实验室中质谱仪的使用使本科生和研究生受益。

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professor Robert K. Boeckman Jr. and Joseph P. Dinnocenzo of the University of Rochester will acquire a high sensitivity, ion trap mass spectrometer equipped with a modern liquid chromatograph (LC-MS), as well as electrospray (ES) and atmospheric pressure chemical ionization (APCI) ion sources. It will be employed in a variety of research projects including the study of: a) the chemistry of group 14 cation radical intermediates; b) the design and development of novel chemo-enzymatic and chemo-biosynthetic methods; c) the chemistry and properties of complexes of the heavier platinum and coinage group elements; d) the discovery of new reactions for the synthesis of natural products; e) the properties of unsaturated, reactive complexes of iron that are catalytically active; and, f) the activation of C-H, C-S, C-CN, and C-F bonds using isotopically labeled transition metal complexes.Mass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Chromatography is an isolation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed by the mass spectrometer. These are widely used analytical techniques to identify and quantify the chemical composition of a sample. The acquisition will benefit undergraduate and graduate students through research programs in the Department and through utilization of the mass spectrometer in the undergraduate chemistry laboratories.