Biphasic Catalysis Using Soluble Polymer Supports

化学催化计划支持德克萨斯A&M大学的David E.Bergbreiter教授的一个研究项目，该项目将在不相容的溶剂混合物中使用相选择性可溶聚合物结合催化剂，以解决合成和催化中的重要挑战，并将在催化、合成、绿色化学和聚合物化学领域产生影响。这项拟议的研究将扩展PI过去的发现，即在均相溶液中使用聚合物结合的催化剂在油包油乳状液中进行反应。所提出的催化剂固定化化学主要基于可溶聚合物载体的性质。利用以前工作中开发的化学方法，可以制备各种均相催化剂，并将它们分离并浓缩在油包油乳状液的不连续相中。酯交换催化剂、有机金属催化剂和有机催化剂都将被研究。要研究的反应是使用几种不同的方法进行的大环化反应，如酯交换、烯烃歧化、Baylis-Hilman反应和环氧化物上的羧酸加成。在国家科学基金会化学部化学催化计划的支持下，Bergbreiter博士将进行研究，不仅适用于多种类型的大环化反应(内酯、环氧化物、Baylis-Hilmman)，还包括精心而巧妙的研究，旨在优化反应速度、催化剂回收和从产品中移除催化剂。Bergbreiter？S教授的工作也对技术领域产生了影响，在技术领域，早期的工作是杜邦最近描述的一种工艺的基础，该工艺是一种商业上可行的方法，可以生产出含有低挥发性有机化合物(VOC)的透明涂料，用于汽车涂装应用。这项工作的更广泛影响包括培养本科生、博士后和博士后。伯格布雷特教授成功地引进了来自德克萨斯农工大学和其他地方的本科生进行研究。他的研究项目预计将继续有相当大比例的学生来自代表性不足的群体。目前的方案包括34%的女性和38%参与该项目的本科生或研究生中代表不足的群体的学生。未来，通过瞄准德克萨斯州为代表不足的群体提供服务的学校，这些比例将增加到50%。通过与卡塔尔的一所本科机构以及日本和泰国的大学合作，将实现国际推广，这将拓宽他的学生的文化经验。

The Chemical Catalysis Program supports Professor David E. Bergbreiter at Texas A&M University for a research project that will use phase-selectively soluble polymer-bound catalysts in immiscible solvent mixtures to address important challenges in synthesis and catalysis and will have an effect on the areas of catalysis, synthesis, Green chemistry and polymer chemistry. The proposed research will extend the PI's past discoveries on the use of polymer-bound catalysts in homogeneous solutions to conduct reactions in oil-in-oil emulsions. The catalyst immobilization chemistry proposed is based principally on the properties of the soluble polymer support. Using chemistry developed in prior work will allow the preparation of a variety of homogeneous catalysts, and phase segregate and concentrate them in the discontinuous phase of oil-in-oil emulsions. Transesterification catalysts, organometallic catalysts and organocatalysts will all be studied. The reactions to be studied are macrocyclizations using several different methods such as transesterification, olefin metathesis, Baylis-Hilman reactions, and carboxylic acid additions to epoxides.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Dr. Bergbreiter will perform research that will not only apply to multiple types of macrocyclizations (lactones, epoxides, Baylis-Hilmman), but also include careful and clever studies designed to optimize reaction rates, catalyst recovery, and removal of catalysts from products. Professor Bergbreiter?s work has also had an impact in the technology arena where earlier work was the basis of a recently described process by DuPont for a commercially viable route to clearcoats containing low volatile organic compounds (VOC) for automotive finishing applications. Broader impacts of this work include the training of undergraduate, PhD, and postdoctoral students. Professor Bergbreiter has had success introducing undergraduates both from Texas A&M and elsewhere to research. His research program is expected to continue to involve a significant percentage of students from underrepresented groups. The current program included 34% women and 38% students from underrepresented groups among the undergraduates or graduate students who worked on the project. These percentages will increase to 50% in the future by targeting schools in Texas that serve underrepresented groups. International outreach will be achieved by working with an undergraduate institution in Qatar, and with universities in Japan and Thailand, which will broaden the cultural experiences of his students.