Micellular Electrospray Synthesis of Magnetic Quantum Dots

ID：MPS/DMR/BMAT（7623）1206745 PI：Winter，Jessica ORG：俄亥俄州州立大学磁性量子点的微细胞电喷雾合成智力优势：这项研究将研究新的合成路线，以联合量子点和磁性纳米粒子。 这些磁性量子点是荧光的，并对磁场做出响应，因此可以用于各种应用，包括多模态成像，分离和研究力在细胞功能中的作用。 这些纳米复合材料将通过自下而上的组装策略（胶束自组装）与自上而下的过程（电流体动力喷雾）相结合来生产。 在所提出的方法中，电喷雾将产生连续、均匀、大表面积的乳液液滴，所述乳液液滴将通过它们与水的界面不稳定性转化为胶束。 由于电喷雾颗粒的形态受到严格控制，胶束电喷雾应该能够实现更大的过程控制和改善的颗粒均匀性、再现性和规模。 鉴于电喷雾以前没有被用来检查胶束结构，我们将首先探讨空胶束生产的反应条件的影响，然后研究纳米粒子负载对胶束的影响。 所产生的颗粒将通过单一纳米复合材料分析技术进行表征。 单粒子的磁性表征在纳米尺度上还没有被证明。 这种方法可以应用于几乎任何小于胶束核心的疏水结构，从而产生各种各样的纳米复合材料。 这些研究也将增加对胶束-纳米颗粒组装体的理解，这与空胶束或胶束包裹分子不同。更广泛的重要性：这项研究将由研究生、本科生和高中研究人员组成的不同团队执行。 研究成果将通过一个独特的教育战略，结合教学和推广，为K-14学生开发课程材料和实验演示传播。 此外，拟议的工作将被纳入由非营利合作伙伴EdHeads开发的教育视频游戏，以提高K-12 STEM和纳米技术的认识。

ID: MPS/DMR/BMAT(7623) 1206745 PI: Winter, Jessica ORG: Ohio State UniversityTitle: Micellular Electrospray Synthesis of Magnetic Quantum DotsINTELLECTUAL MERIT: This research will examine new synthesis routes to unite quantum dots and magnetic nanoparticles. These magnetic quantum dots are fluorescent and respond to a magnetic field and could thus be used in a variety of applications, including multimodal imaging, separations, and studies of the role of force in cell function. These nanocomposites will be produced by combining a bottom up assembly strategy (micellular self-assembly) with a top down process (electrohydrodynamic spraying). In the proposed approach, electrospray will generate continuous, uniform, large surface area emulsion droplets that will be transformed to micelles via their interfacial instability with water. Because the morphology of electrospray particles is tightly controlled, micellular electrospray should enable greater process control and improved particle uniformity, reproducibility, and scale. Given that electrospray has not previously been used to examine micellular structures, we will first explore the influence of reaction conditions on empty micelle production, and then investigate the influence of nanoparticle loading on micelles. Particles produced will be characterized through single nanocomposite analysis techniques. Single particle magnetic characterization at the nanoscale has not previously been demonstrated. This approach could be applied to virtually any hydrophobic structure smaller than the micelle core, thus producing a wide variety of nanocomposites. These studies will also increase understanding of micelle-nanoparticle assemblies, which are distinct from empty micelles or micelles encapsulating molecules.BROADER IMPACTS: This research will be executed by diverse teams of graduate, undergraduate, and high school researchers. Research results will be disseminated through a unique educational strategy that combines teaching and outreach to develop course materials and experimental demonstrations for K-14 students. Additionally, the proposed work will be incorporated into an educational video game developed by non-profit partner EdHeads to increase K-12 STEM and nanotechnology awareness.