MRI: Acquisition of Bruker EMXplus series EPR Spectrometer

在主要研究仪器项目（MRI）和化学研究仪器项目（CRIF）的支持下，贝勒大学的Patrick Farmer教授和他的同事Caleb Martin、Kevin Pinney、Bryan Shaw和John Wood将获得一台电子顺磁共振（EPR）光谱仪。该仪器将允许在各种领域进行研究，例如那些提供有关生物相关物种在拥有不成对电子时如何表现的见解。一般来说，EPR光谱仪产生分子和固态材料的几何和电子结构的详细信息。它还可用于获取自由基的寿命信息，这些自由基是参与有价值的化学转化以及病理性肿瘤生长起始的短命、高活性物质。这些研究将影响许多领域，从无机和有机分子的合成到新型固态材料的开发，再到磁性和生物化合物。从正在进行的研究中获得灵感，该仪器将成为贝勒大学、奥斯汀学院、德克萨斯大学泰勒分校和德克萨斯路德大学本科和研究生阶段研究和教学的一个组成部分。该奖项旨在加强各级的研究和教育，特别是在以下领域：(a)研究HNO的生物配合化学；(b)研究超氧化物歧化酶-1和其他金属蛋白的电荷调节机制；(c)研究黑色素的促氧化化学；(d)生物还原肿瘤微环境的设计、合成与评价；(e)分析三烷基硼烷水配合物的自由基反应；(f)研究硼自由基、吡啶膦/氧化膦配位化学。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Patrick Farmer from Baylor University and colleagues Caleb Martin, Kevin Pinney, Bryan Shaw and John Wood will acquire an electron paramagentic resonance (EPR) spectrometer. This instrument will allow research in a variety of fields such as those that provide insight on how biologically relevant species behave when they possess unpaired electrons. In general, an EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of pathological tumor growth. These studies will impact a number of areas, from the synthesis of inorganic and organic molecules to the development of new solid state materials to compounds of magnetic and biological interest. Employing examples inspired from ongoing research, this instrument will be an integral part of research and teaching at the undergraduate and graduate levels at Baylor University as well as Austin College, the University of Texas at Tyler and Texas Lutheran University.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) investigating biocoordination chemistry of HNO; (b) studying the mechanism of charge regulation in superoxide dismutase-1 and other metalloproteins; (c) studying the pro-oxidant chemistry of melanins; (d) designing, synthesizing and evaluating bioreductive tumor microenvironment; (e) analyzing radical reactions of trialkylborane water complexes; and (f) studying boron radicals, pyridyl phosphine/phosphine oxide coordination chemistry.