MRI: Acquisition of a 500 MHz NMR Spectrometer to Enhance Undergraduate Research at Wellesley College

该奖项来自重大研究仪器计划(MRI)以及化学研究仪器(CRIF)和化学合成(SYN)计划的额外支持，用于资助韦尔斯利学院购买500 MHz核磁共振波谱仪。核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行现代研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该仪器用于研究具有潜在抗癌和抗结核作用的有机小分子、DNA寡核苷酸的突变以及用于成像和医学用途的修饰纳米颗粒。该光谱仪也是培养女本科生不可或缺的组成部分。它被学生们用在课程和研究项目中。该建议旨在加强各级的研究和教育，特别是在下列领域：(A)测量包含基本位点损伤的DNA双链中碱基对开放的平衡常数；(B)表征多用途纳米颗粒的官能化和磁性；(C)确定具有抗肿瘤特性的新型香豆素衍生物的结构；(D)表征多种吡唑类化合物作为潜在的抗结核药物；(E)合成光反应小分子以帮助理解GCPR跨膜蛋白结构；以及(F)使用NOE方法表征N-取代吡唑的区域化学。

This award from the Major Research Instrumentation Program (MRI) as well as additional support from the Chemistry Research Instrumentation (CRIF) and the Chemical Synthesis (SYN) Programs funds the acquisition of a 500 MHz NMR spectrometer by Wellesley College. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out modern research. This instrument is used in research on small organic molecules with potential anti-cancer and anti-tubercular properties, mutation of DNA oligonucleotides, and modified nanoparticles for imaging and medicinal usages. This spectrometer is also an integral component in training female undergraduate students. It is used by the students in courses and in their research projects. The proposal is aimed at enhancing research and education at all levels, especially in areas such as: (a) measuring equilibrium constants for base pair opening in DNA duplexes containing an abasic site lesion; (b) characterizing functionalization and magnetic properties of multipurpose nanoparticles; (c) determining the structure of novel coumarin derivatives with anti-tumor properties; (d) characterizing diverse pyrazolines as potential antitubercular agents; (e) synthesizing photoreactive small molecules to aid in the understanding of a GCPR transmembrane protein structure; and (f) using NOE methods to characterize the regiochemistry of N-substituted pyrazoles.