MRI: Acquisition of a 600 MHz NMR Spectrometer for Chemistry

在主要研究仪器计划(MRI)的这一奖项以及化学研究仪器(CRIF)和生命过程化学(CLP)计划的支持下，埃默里大学将获得一台600 MHz核磁共振光谱仪。该仪器将推动合成有机化学、催化和新方法开发、天然产物和材料表征、无机化学、生物分子化学以及光谱信息与理论研究的整合等领域的研究活动。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行现代研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这一工具也将是培养本科生和研究生不可或缺的组成部分。该奖项旨在加强以下领域的研究：(A)研究天然产物合成；(B)研究反应性、催化和合成策略，以推动药物和材料创新；(C)开发立体选择方法及其在全合成和药物发现中的应用；(D)发现有特定目的应用于过渡金属化学的反应；(E)了解与人类健康和疾病有关的信号通路；(F)探索具有多种用途的功能性和定义明确的大分子结构；(G)研究多金属氧酸盐(POM)络合物和多金属氧酸盐材料及其作为催化剂的用途；(H)开发从传统惰性起始材料的选择性活化和功能化的合成方法；(I)开发用于正电子发射断层扫描的小分子放射性示踪剂；(I)研究药用植物的抗菌原理；以及(J)发现治疗剂及其与目标蛋白质相互作用的结构基础。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation (CRIF) and Chemistry of Life Processes (CLP) programs, Emory University will acquire a 600 MHz NMR spectrometer. This instrumentation will advance research activities spanning the fields of synthetic organic chemistry, catalysis and new methodology development, natural products and materials characterization, inorganic chemistry, biomolecular chemistry, and the integration of spectroscopic information with theoretical studies. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out modern research. This instrument will also be an integral component in training undergraduate and graduate students. It will advance the teaching and research training mission of the department by providing hands-on NMR experience in applying advanced NMR topics covered in core academic and supplemental summer courses.The award is aimed at enhancing research in areas such as (a) studying natural product synthesis; (b) studying reactivity, catalysis and synthetic strategy, to drive pharmaceutical and materials innovation; (c) developing stereoselective methods and their applications in total synthesis and drug discovery; (d) discovering reactions with a particular aim to apply to transition metal chemistry; (e) understanding signaling pathways involved in human health and disease; (f) exploring functional and well-defined macromolecular structures with various applications; (g) studying polyoxometalate (POM) complexes and POM-based materials, and their uses as catalysts; (h) developing synthetic methods in contexts ranging from selective activation and functionalization of traditionally inert starting materials; (i) developing small molecular radiotracers for positron emission tomography; (i) studying antimicrobial principles in medicinal plants; and (j) discovering therapeutic agents and the structural basis for their interactions with target proteins.