SusCHEM: Development of New Reductive Transformations Utilizing First-Row Metal Catalysis

化学系的化学合成项目支持约翰·蒙哥马利教授的研究。Montgomery教授是密歇根大学化学系的一名教员。该项目的目标是开发由地球上丰富的金属镍和铜催化的合成有机化学的新工艺。与现有的替代方法相比，新工艺具有更好的稳定性和反应性，更低的成本和更容易获得。新的催化剂被用来发现新的有机转化的现成的底物。这些努力创造了多功能和高效的新催化剂和合成程序，使高价值产品的创造成为可能。该产品以环境可持续的方式从简单和广泛可用的原料制备而成。从事这项工作的学生在发现新反应、开发合成方法、有机金属化学和机械化学方面受到训练。重点放在研究生的职业发展上。有兴趣在本科院校就业的研究生有机会在那种环境中工作。通过与本科院校的一个非常成功的实验室合作，研究生获得进行研究和指导本科生的经验。其他学生有机会在国际研究实验室进行合作研究。蒙哥马利教授和他的研究团队还参与了为底特律大都会地区的年轻学生提供吸引人的科学接触的推广活动。这些活动影响了许多年轻学生的学术经历，包括代表性不足的少数民族，同时与他们分享化学领域的兴奋。与贵金属催化剂相比，镍和铜催化剂具有独特的反应活性和正交性能。该研究的主要重点是利用镍和铜的特性反应性来发现和开发其他金属未知的合成工艺，并提供快速获得高价值产品的途径。特别是，硅氧基芳烃是一种未充分利用但广泛可用且价格低廉的有机底物，广泛应用于碳-氢、碳-硅和碳-碳成键工艺。在涉及铜催化的工作中，通过同时结合多个硼和氰基官能团的过程，设计了具有两个或多个不饱和结构单元的底物衍生的新型级联过程。教育计划包括创新实践，为密歇根大学的研究生提供职业发展培训和国际研究机会。

The Chemical Synthesis Program of the Chemistry Division supports the research by Professor John Montgomery. Professor Montgomery is a faculty member in the Department of Chemistry at the University of Michigan. The goal of this project is to develop new processes for synthetic organic chemistry that are catalyzed by the earth-abundant metals nickel and copper. The new processes offer improved stability and reactivity, lower cost, and ease of access compared with existing alternatives. The new catalysts are being used to discover new organic transformations of readily available substrates. These efforts create versatile and efficient new catalysts and synthetic procedures that enable the creation of high-value products. The products are prepared from simple and widely available feedstocks in an environmentally sustainable manner. Students engaged in the work are trained in the discovery of new reactions, synthetic methods development, organometallic chemistry, and mechanistic chemistry. A substantial emphasis is placed on the career development of graduate students. Graduate students interested in employment at undergraduate institutions have they opportunity to work in that environment. Through a collaboration with a highly successful laboratory at an undergraduate institution, the graduate student gains experience conducting research and mentoring undergraduates. Other students have the opportunity to conduct collaborative research in international research labs.Professor Montgomery and his research team also are involved in outreach activities that provide engaging exposure to science for young students from the Detroit metropolitan area. These activities impact the academic experiences of many young students including underrepresented minorities while sharing with them the excitement of chemistry fields.Compared with precious metal counterparts, nickel and copper catalysts offer unique reactivity and orthogonal capabilities. A primary focus of the research is to capitalize on the characteristic reactivity of nickel and copper to discover and develop synthetic processes that are unknown with other metals and that provide rapid access to high-value products. In particular, silyloxyarenes, which are an underutilized but widely available and inexpensive class of organic substrates, are employed in a wide array of carbon-hydrogen, carbon-silicon, and carbon-carbon bond-forming processes. In efforts involving copper catalysis, novel cascade processes that derivatize substrates possessing two or more unsaturated structural units are devised through processes that simultaneously incorporate multiple boron and cyano functional groups. The education plans involve innovative practices to provide career development training and international research opportunities to graduate students at the University of Michigan.