MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer with Cryoprobe

该奖项由主要研究仪器（MRI）、化学研究仪器和刺激竞争性研究的既定计划（EPSCoR）计划支持。克莱姆森大学的Leah Casabianca教授和他的同事Mark Thies， Julia Brumaghim， Sourav Saham和Nishanth Tharayil正在获得一台配备了冷冻探针的500 MHz核磁共振（NMR）光谱仪。该光谱仪允许在各种领域的研究，如那些加速具有重要经济意义的化学反应，以及对生物相关物种的研究。总的来说，核磁共振波谱是化学家研究分子结构的有力工具。核磁共振用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固体状态下分子之间不断变化的相互作用。这些核磁共振研究的结果对合成有机/无机化学、材料化学、法医学和生物化学都有影响。该仪器是本科生教学和研究中不可或缺的一部分。来自本科生研究经验（REU）项目的学生也参与了该仪器的使用。这种核磁共振光谱仪增强了各级的研究和教育。它有利于研究人员利用77-硒核磁共振光谱探索硒的抗氧化机制，研究纳米颗粒的毒性，以及确定离子聚合物的动态时间和长度尺度。该仪器用于研究阴离子和离子对识别和刺激响应功能材料。研究人员正在分析碳量子点的生物偶联物，并开展土壤固碳的生物地球化学研究。该光谱仪还用于研究氟化学，为高价值应用量身定制木质素性质，合成肽类聚合物以及研究合成有机化学的应用。

This award is supported by the Major Research Instrumentation (MRI), the Chemistry Research Instrumentation, and the Established Program to Stimulate Competitive Research (EPSCoR) Programs. Professor Leah Casabianca from Clemson University and colleagues Mark Thies, Julia Brumaghim, Sourav Saham, and Nishanth Tharayil are acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a cryoprobe. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically-relevant species. In general, NMR spectroscopy is a powerful tool available to chemists for the structural study molecules. An NMR is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the changing interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry, forensics, and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students. Students from a Research Experiences for Undergraduates (REU) program are also involved in the use of the instrument.This NMR spectrometer enhances research and education at all levels. It benefits researchers exploring selenium antioxidant mechanisms using 77-selenium NMR spectroscopy, studying nanoparticle toxicity, and determining dynamic time and length scales in ionic polymers. The instrumentation is employed in studying anion and ion pair recognition and stimuli-responsive functional materials. Researchers are analyzing bioconjugates of carbon quantum dots and carrying out biogeochemical research on soil carbon sequestration. The spectrometer is also used for studying fluorine chemistry, tailoring lignin properties for high-value applications, synthesizing peptoid polymers, and studying applications to synthetic organic chemistry.