The molecular basis of macropinocytosis in mammalian cells: the composition of endosome proteins and their function

单个细胞通过巨噬细胞作用与周围环境进行交流，这一过程涉及细胞外空间与称为内体的细胞特殊区域之间的物质交换。这是哺乳动物细胞中一个重要的过程，对许多组织的正常运作至关重要。本项目将在分子水平上促进对巨噬细胞增多症的认识。该项目与了解正常细胞的功能和一些病原体进入细胞的方式有关，也与了解肿瘤进展和转移的过程有关。

Individual cells communicate with their immediate environment by the process of macropinocytosis, a process that involves the exchange of materials between the extracellular space and a specialised region of the cell termed endosomes. It is an important process in mammalian cells being essential to the correct functioning of many tissues. This project will advance understanding of macropinocytosis at a molecular level. The project is relevant to understanding the functioning of normal cells and the means by which some pathogens can enter cells and also understanding processes involved in tumour progression and metastasis.