Molecular Interactions in the Eubacterial Replisome: A Paradigm for Study of Dynamic Macromolecular Machines

许多致病菌已经对常用的抗生素产生了耐药性，迫切需要新的药物来杀死它们。细菌在分裂成两个新细胞之前进行染色体复制是细菌生存的必要条件，因此DNA合成是开发新抗生素的一个很好的目标过程。该项目将使用澳大利亚和海外几个实验室中最先进的设备，对复制DNA的分子机器如何工作进行新的理解。这些知识可能会导致新的药物，并将为我们提供关于细胞机器如何运作的新信息。。

Many pathogenic bacteria have developed resistance to antibiotics in common use, and new drugs are urgently required to kill them. Copying of their chromosomes before they divide into two new cells is essential for bacteria to live, so DNA synthesis is a good process to target for development of new antibiotics. This project will use state-of-the-art equipment available in several laboratories in Australia and overseas to develop new understanding of how the molecular machine that copies DNA works. This k nowledge could lead to new drugs, and will give us new information about how cellular machines function.