Study of activated carbon adsorbing anticancer drugs for chemotherapy of lymphnode metastasis and peritoneal metastasis.

本项目研制了新型药物剂型“活性炭吸附抗癌药物”。活性炭具有众多的微粒，具有很大的表面积，可以在表面吸附或解吸药物。当它被注射到组织中时，它被吸收到毛细淋巴管中，并立即到达区域淋巴结。当它被注射到癌性胸膜腔或腹腔时，它被吸附在癌细胞和浆膜表面。利用活性炭的这些特性，我们制备了吸附丝裂霉素C（MMC-CH）或阿霉素（ADM-CH）的活性炭，用于淋巴结转移和腹膜转移的化疗。动物实验表明，活性炭吸附MMC或ADM对淋巴结转移和胸、腹腔转移有明显的抑制作用，并将MMC-CH和ADM-CH应用于胃癌、乳腺癌和结肠癌淋巴结转移的治疗。除淋巴结转移化疗外，活性炭染黑的淋巴结易于被外科医生识别，并可切除大量淋巴结。73例癌性腹膜炎患者中45例对MMC-CH有反应，未见严重不良反应。因此，活性炭吸附抗癌药物对淋巴结转移和胸、腹膜转移的化疗是非常有用的。

In this project new drug dosage form "activated carbon adsorbing anticancer drug" was produced. Activated carbon has numerous microposes that possesses great surface area and can adsorb or desorb the drug on the surface. When it is injected into tissues, it is adsorbed into the lymphatic capillaries and immediately reaches the regional lymph nodes. When it is injected into a cancerous pleural or abdominal cavity, it is adsorbed on cancer and serosal surface. Using these properties of the activated carbon, we have prepared activated carbon adsorbing Mitomycin C (MMC-CH) or Adriamicin (ADM-CH) for chemotherapy of lymphnodes metastasis and peritoneal metastasis. Animal experiments revealed that activated carbon adsorbing MMC or ADM was very effective on lymphnode metastasis and pleural or peritoneal metastasis.MMC-CH and ADM-CH were applied to the patients with carcinoma of the stomach, breast and colon for the treatment of lymphnode metastasis. Beside the chemotherapy of lymphnode metastasis, lymphnodes stained in black by activated carbon were easily identified by surgeons,and many lymphnodes were dissected.Forty five of 73 patients with carcinomatous peritonitis responded to MMC-CH. No serious adverse effect was observed.As a result, activated carbon adsorbing anticancer drug was very useful for chemotherapy of lymphnode metastasis and pleural or peritoneal metastasis.