Common roles of macrophage proliferation and polarization in type 2 diabetes and atherosclerosis.

糖尿病模型中炎性M1巨噬细胞浸润胰岛的db/db显著增加，提示M1巨噬细胞参与2型糖尿病b细胞功能障碍。我们在清道夫受体启动子的控制下，培育了含有p27 cDNA的巨噬细胞特异性增殖受限小鼠。然而，该突变小鼠的雄性和雌性都是不育的。Tg小鼠骨髓源性巨噬细胞p27 mRNA表达显著升高，巨噬细胞增殖受到抑制。巨噬细胞中p27的表达对不孕症的影响将是另一个需要进一步研究的项目。

Inflammatory M1 macrophage infiltration into pancreatic isletsin diabetic model db/db was significantly increased, which suggested the implication of M1 macrophage in b cell dysfunction in type 2 diabetes. We generated the transgenic mouse containing p27 cDNA under the control of scavenger receptor promoter, which is macrophage-specific proliferation restricted mouse. However both male and female of this mutant mouse were infertile. The p27 mRNA expression was significantly increased in bone marrow-derived macrophage from Tg mice, and the proliferation of these macrophages were restricted. The effect of p27 expression in macrophage on infertility will be another project to be studied farther.