Synthesis of Sequential Polypeptides Having Biological Activity

最近，我们找到了用二苯基磷酰叠氮化物(DPPA)作为聚合试剂合成多肽的新方法。该方法适用于多肽的聚合反应，得到类蛋白质序列多肽。本研究制备了各种具有生物活性的序列多肽，并对其构象及其与DNA等生物聚合物的相互作用进行了研究，以阐明其作为生物功能材料的可能性。并对这些序列多肽在医学上的应用进行了探讨。

Recently, we found the new synthetic method of polypeptides to employ diphenylphosphoryl azide(DPPA) as a polymerization reagent. This method is adequate for the polymerization of peptides to give protein-like sequentialpolypeptides. In the present investigation, various types of biologically active sequential polypeptides were prepared, and their conformation and the interactions with biopolymers such as DNA were investigated to clarify their possibility as biofunctional materials. The medical application of these sequential polypeptides were also examined.