Is endocapillary proliferative glomerulonephritis of pigs post-streptococcal?

对自然发生的猪肾小球肾炎的发病率和病理实体进行了检测。此外，还通过瘤体内接种β-溶血性链球菌(B、C、E、N、P、R、U五种血清型)的方法复制肾炎。在2129头0~6月龄以上的猪中，16头6月龄出现毛细血管内增生性肾小球肾炎(EPGN)，572头出现系膜增生性肾小球肾炎(&lt；PGN)，28头出现Ig A肾炎。结论：1.后两种肾炎的发病率随着年龄的增长而逐渐增加。病理发现EPGN表现为肾小球小球内弥漫性毛细血管内细胞增殖。免疫球蛋白G、免疫球蛋白M和补体C_3在系膜和毛细血管壁上呈颗粒状沉积。在MPGN中，肾小球病变以系膜基质增生为主。MPGN组肾小球免疫复合体未见明显增加。免疫球蛋白A肾炎表现为肾小球内EPGN和MPGN的改变以及小球内IgA的沉积。实验复制连续每日接种链球菌6个月未引起明显的肾小球病变。

Incidence and pathological entity of naturally occurring glanerulonephritis of pigs were examined. In addition, experimental reproduction of the nephritis was performed by intratonsillar inoculation of beta-hemolytic Streptococcus sp.(serotypes B,C,E,N,P,,R,U) in piglets.1 . IncidenceOf 2129 pigs aged fran 0 to more than 6 months old, 16 six-month-old pigs showed endocapillary proliferative glomerulonephritis(EPGN), and 572 and 28 pigs of various ages exhibited mesangio- proliferative glomerulonephritis(<PGN) and Ig A nephritis, respectively. The incidence of the latter two nephritis gradually increased with aging.2. Pathological findingsEPGN showed diffuse global intracapillary cell proliferation in the glomerular tuft. Ig G, Ig M and C_3 deposited granularly in the mesangium and capillary wall. In MPGN, proliferation of mesangial matrix dominated the glomerular lesion. No significant increase of immune-complex was observed in the MPGN-affected glomeruli. Ig A nephritis showed glomerular ar changes of EPGN and MPGN in each glomerulus as well as a deposition of Ig A in the tuft.3. Experimental reproductionNo significant glomerular lesions were induced by the successive daily inoculation of Streptococcus for 6 months.