DEVELOPMENT OF CATHETER SYSTEMS FOR ENDOVASCULAR THERAPY AND ESTABLISHMENT OF GUIDELINE FOR ITS SAFETY USE

1. 用于可拆卸球囊导管的固化液体：例如，在血管内手术中，为了永久阻止血液流入动脉瘤，导管经皮插入动脉，球囊被固化液体定位并膨胀，然后释放到病变部位。以葡萄糖氧化酶为原料，研制了一种可在氧气通过球囊壁连续进料条件下固化的新型球囊固化液。这种固化液体即使在氧气和水的存在下也能固化。血管内手术已安全进行。一种用于动静脉畸形栓塞的新型液体材料：我们开发了一种用于动静脉畸形栓塞的液体材料，它是一种甲基丙烯酸酯共聚物和溶解在乙醇-水混合物中的iopamidol的混合物。当液体物质通过导管注入血液时，乙醇迅速扩散到血液中，形成甲基丙烯酸酯软海绵，阻塞喂食器和病灶。该材料无粘连性，用于动静脉畸形的临床栓塞治疗，效果满意。聚合物表面的润滑：研究了疏水聚合物表面接枝聚合的方法。(1)采用一种含乙烯基的有机硅预聚物，该预聚物可通过自由基机理固化。通过在丙烯酰胺单体溶液中使用高压灭菌器加热由有机硅预聚物和过氧化物混合物制成的薄膜，可以很容易地接枝聚合丙烯酰胺。(2)利用光辐照技术研究了丙烯酰胺在聚对苯二甲酸乙酯薄膜上的表面接枝聚合。这些程序可以直接适用于润滑导管。

1. SOLIDIFYING LIQUID FOR DETACHABLE BALLOON CATHETER : In endovascular surgery, to permanently hinder blood inflow into an aneurysm for example, a catheter is percutaneously introduced into an artery and the balloon is positioned and inflated by a solidifying liquid and then released into the diseased part. A novel solidifying liquid for inflated balloon curable under the continuous feeding of oxygen through the wall of the balloon has been developed using glucose oxidase. This solidifying liquid cured even in the presence of oxygen and water. The endovascular surgery has carried out safely using it.2. A NEW LIQUID MATERIAL FOR EMBOLIZATION OF ARTERIOVENOUS MALFORMATION : We have developed a liquid material for embolization of arteriovenous malformations that is a mixture of a methacrylates copolymer and iopamidol dissolved in an ethanol-water mixture. When the liquid material is injected into blood through a catheter, ethanol rapidly diffuses into blood and forms an methacrylates soft sponge that obstructs both the feeder and the nidus. The material, which is not adhesive, was used for clinical embolization of arteriovenous malformations with satisfactory results.3. LUBRICATION OF POLYMER SURFACE : Methods were developed for surface graft polymerization onto hydrophobic polymers. (1) A silicone prepolymer carrying vinyl groups, which can be cured by a free-radical mechanism, was used. Acrylamide can be easily graft polymerized by simply heating the films made of a mixture of the silicone prepolymer and peroxide in an acrylamide monomer solution using autoclave. (2) Surface graft polymerization of acrylamide onto a poly(ethylene terephthalate) film has been investigated using a photo irradiation technique. Those procedures can be directly applicable to lubricate catheters.