Enhanced high-field nuclear magnetic resonance spectroscopy

核磁共振（NMR）光谱是化学中最强大的分析工具，范围从小分子到大生物分子（如蛋白质和DNA）的3D结构测定。该应用适用于提供尽可能高的检测灵敏度的探头，比当前探头高约2.5倍，当前探头是借来的物品，部分有缺陷。新的探测器对于澳大利亚国立大学800 MHz NMR光谱仪的全面运行至关重要，该光谱仪投资400万美元。通过将测量加速6倍，并且对盐的敏感性大大降低，可以研究更大范围的蛋白质系统，包括重要的药物靶点，如CoV-2主要蛋白酶。

Nuclear magnetic resonance (NMR) spectroscopy is the most powerful analytical tool in chemistry, ranging from small molecules to 3D structure determinations of large biomolecules such as proteins and DNA. This application is for a probe that offers the highest possible sensitivity of detection, about 2.5 times higher than the current probe, which is a loaned item and partly defect. The new probe is essential to regain full operation of the 800 MHz NMR spectrometer at the Australian National University, which constitutes a $4M investment. By accelerating measurements 6-fold and being much less sensitive to salt, a greater range of protein systems can be studied, including important drug targets such as the CoV-2 main protease.