Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses

该项目的总体目标是提供表面纳米形貌如何影响炎症反应的机械性理解。最近，我们发现，表面纳米拓扑术引起的吸附蛋白的构象变化可以激活或灭活免疫细胞。这些令人兴奋的发现很重要，因为它们表明，有可能以一种导致所需和可预测的炎症水平的方式来设计生物医学设备表面的纳米拓扑术。该项目的成果将创造新的基础知识，在未来可以指导下一代生物材料的开发，能够控制和指导人体的炎症反应。

The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation. The outcomes of the project will create new fundamental knowledge that in the future can instruct the development of the next generation of biomaterials capable of controlling and directing the body’s inflammatory responses.