Refinement of dynamic combinatorial chemistry as a drug discovery tool

药物化学不断受到挑战，需要开发有效的方法来合成用于药物发现的化合物。随着人类基因组计划的完成，新蛋白质的克隆和表达将以更快的速度进行。在缺乏目标蛋白的生化知识的情况下，人们对扩展化合物文库的结构和生物多样性的技术越来越感兴趣。动态组合化学是一项创新技术，具有支持从集中到多样化化合物库的转变的能力。本申请寻求资金，以完善动态组合化学成为有效的药物发现工具。

Medicinal chemistry is constantly being challenged to develop efficient methodologies for the synthesis of compounds for drug discovery. Following completion of the Human Genome project, the cloning and expression of new proteins will proceed at an accelerated rate. In the absence of biochemical knowledge of the target protein there is a growing interest in techniques that expand the structural and biological diversity of compound libraries. Dynamic combinatorial chemistry is an innovative technology with the capacity for supporting the shift from focussed to diverse compound libraries. This application seeks funding to refine dynamic combinatorial chemistry into an effective drug discovery tool.