Development of Biomedical Polymeric Composite Materials with Functional Gradient Based on Biodegradable Polymers and Characterization

近年来，自然界中的功能梯度材料因其优异的性能而成为材料科学领域的研究热点。在本研究中，本文建立了一种利用傅里叶变换红外光谱（FT-IR）技术定量分析聚合物梯度膜沿着组分分布的方法，并将其应用于生物可降解和生物相容性高分子复合材料的研究（环氧乙烷）/聚（3-羟基丁酸酯）共混物薄膜的组成梯度通过压缩成型或溶液扩散方法制备。连续组成的梯度结构，成功地创建了通过使用的方法的相互扩散之间的界面上的聚（丁二酸丁二醇酯）和聚（环氧乙烷）层在温度高于熔点的两种组分聚合物。此外，在低分子量化合物联苯酚作为相容性增强剂的存在下，成功地制备了在膜厚度方向上具有组成梯度的生物可降解的不相容的聚（己二酸丁二醇酯-共-对苯二甲酸丁二醇酯）/聚（环氧乙烷）聚合物共混膜。

Recently, naturally inspired functional gradient materials have attracted much attention as a field of material science due to their excellent properties. In this research, several methodologies to generate the compositional and functional gradient structures in the polymeric composite materials have been developed and characterized their structures and properties.A method for quantitative analysis of the compositional distribution along the cross-section in the polymeric gradient films by FT-IR microspectroscopy was developed and it was applied to the biodegradable and biocompatible poly(ethylene oxide)/poly(3-hydroxybutyrate) blend films with compositional gradient fabricated by compression molding or solution diffusion methods. A continuous compositional gradient structure was successfully created by using a method of interdiffusion across the interface between poly(butylene succinate) and poly(ethylene oxide) layers at a temperature above the melting points of both component polymers. Further, a biodegradable immiscible poly(butylenes adipate-co-butylene terephthalate)/poly(ethylene oxide) polymer blend film with compositional gradient in the film thickness direction was successfully prepared in the presence of a low molecular weight compound diphenol as a miscibilityenhancing agent.