Preventative effects of exercise on the cardiovascular disease, ADL and cognitive function of the elderly with metabolic syndrome

代谢综合征(METS)是腹型肥胖、糖耐量低减、高血压和血脂异常的聚集性疾病，是老年人健康的中心问题。本研究旨在探讨运动对老年人心血管疾病、日常生活活动能力及认知功能的影响。运动是治疗METS的重要组成部分，然而，对于老年人来说，继续运动并不总是那么容易。我们首先研究了使用近红外光谱仪(NIRS)对脑功能进行视觉评估可以增加老年人的运动动机。在老年METS患者中，NIBS在词汇流畅性测试中显示出额叶脑血流激活的明显模式。这一观察的意义现在正在调查中，但足够有用，足以让老年人继续进行MetS2练习。调查老年人甲硫氨酸转移症的临床特点。HOMA-IR估计的胰岛素抵抗和Mets的患病率随着年龄的增加而增加。腰围与HOMA-IR呈显著的线性相关，在IDF和AHA-NHLBI与蛋氨酸重叠(肥胖组)时显著升高，在无腹型肥胖(非肥胖组)的AHA-NHLBI-METS中也升高。AHA-NHLBI-METS合并代谢紊乱是预测心血管疾病最有效的指标。蛋氨酸还与老年女性ADL下降有关，与心血管疾病和ADL损害相关。运动对心血管疾病、日常生活能力和脑功能的保护作用有待于进一步的老年人前瞻性研究。

Metabolic syndrome (MetS), clustering of abdominal obesity, glucose intolerance, hypertension and dyslipidemia, is a central concern of the health in the elderly. The aim of this study was to investigate the effects of exercise on the cardiovascular disease, ADL, and cognitive function of the elderly with MetS.1. Exercise is an essential component for the treatment of MetS, however, it is not always easy to continue exercise for the elderly. We first investigated that visual evaluation of brain function by using Near InfraRed Spectrometer (NIRS) could increase the motivation for exercise in the elderly. in the elderly with MetS, NIBS demonstrated the distinct pattern of cerebral blood flow activation in the frontal lobe during the test for word fluency. The meaning of this observation is now under the investigation, but was useful enough to have elderly to continue the exercise for MetS.2. Clinical profile of MetS of the elderly was investigated. Insulin resistance estimated by HOMA-IR and prevalence of MetS increased with age. There was a significant linear association between waist circumference and HOMA-IR, which was highly elevated in IDF & AHA-NHLBI overlapping with MetS (obese MetS), and also elevated in AHA-NHLBI-MetS without abdominal obesity (non-obese MetS). AHA-NHLBI-MetS accompanied by clustering of metabolic disorders was the most effective predictor for cardiovascular diseases. MetS was also associated with decreased ADL in the elderly women.MetS was correlated to cardiovascular disease and ADL impairment. Protective effects of exercise on cardiovascular disease, ADL and brain function should be analyzed by further prospective studies in the elderly.