Cohort study of morbidity and mortality from lifestyle-related diseases among Japanese dietitians

在1999-2000年期间，我们构建了由11,630名注册营养师/营养师组成的JADE（日本营养师流行病学）研究队列，其中包括26个日本饮食协会县分会的会员和6所高等院校的校友营养师。在获得他们的知情同意后，我们通过半定量食物频率问卷（SQFFQ）和生活方式问卷（LSQ）收集饮食习惯和生活方式的基线信息。我们研究了癌症发病率和生活方式相关疾病的死亡率，并调查了饮食习惯和生活方式与生活方式相关疾病的风险或死亡率之间的关系。2007年，我们进行了一项临时调查，使用了一个简短的LSQ和一个简短的FFQ，研究了从基线开始的变化，包括人体测量条件、疾病史和饮食习惯。从这项研究中，我们确认了16例死亡（6名男性和10名女性），并确定了每个潜在的死亡原因。利用2003年日本按性别和年龄分列的死亡率以及研究对象的人年，我们计算了预期死亡人数，并计算了观察死亡人数/预期死亡人数的比率。肿瘤及所有原因的O/E比均小于1，差异均有统计学意义（p<0.01）。

During 1999-2000, we constructed JADE (Japanese Dietitians' Epidemiologic) study cohort consisting of 11,630 dietitians/registered dietitians, including members of 26 Prefectural Branches of the Japanese Dietetic Association, and alumni members of 6 colleges/universities for dietitians. After obtaining their informed consent, we collected baseline information on dietary habits and lifestyle administering a validated semi-quantitative food frequency questionnaire (SQFFQ) and lifestyle questionnaire (LSQ). We studied morbidity of cancer and mortality from lifestyle-related diseases and investigated any associations between dietary habits and lifestyle with risk of or mortality from lifestyle-related diseases. In 2007, we made an interim survey administering an abbreviated LSQ and a short FFQ and studied changes from baseline, including anthropometric conditions, histories of diseases and dietary habits. From this study, we confirmed 16 deaths (6 men and 10 women) and determined each underlying cause of death. Using sex- and age-specific mortality rates of Japan in 2003 and person-years of the study subjects, we calculated the expected number of deaths and computed ratios of observed /expected number of deaths. The O/E ratios for cancers and all causes were less than one with statistical significance (p<0.01).