The analysis of cell-cell barrier function in intestine

上皮细胞片通过紧密连接的细胞间屏障在内部组织区隔和维持局部稳态中起重要作用。使用claudin-15敲除小鼠，我们提出claudin-15基紧密连接的形成对小肠内Na+等离子微环境的组织是重要的。由于葡萄糖等多种营养物质的吸收与Na+的吸收直接耦合，因此这一结果对我们的生活至关重要。

Epithelial cell sheets have an important role in compartmentalizing internal tissues and maintaining their local homeostasis via intercellular barriers consisting of tight junctions. Using claudin-15 knockout mice, we proposed that claudin-15-based formation of tight junctions to organize was important for the ion like Na+ microenvironment in the small intestine. As the absorption of many kinds of nutrients like glucose is coupled directly to Na+ absorption, this result is essential for our life.