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Experimental evidence of in situ capture of endothelial progenitor cells on luminal surface of artificial grafts in bloodstream on porcein model.

Experimental evidence of in situ capture of endothelial progenitor cells on luminal surface of artificial grafts in bloodstream on porcein model.
瓷模型血流中人工移植物管腔表面内皮祖细胞原位捕获的实验证据。
批准号:
20300171
负责人:
MATSUDA Takehisa
金额:
$12.81万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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中文摘要
翻译
本研究旨在原位捕获心血管装置血液接触表面的内皮祖细胞(EPC)。在多种细胞表面受体/Legend对中,只有表面结合的血管内皮生长因子/血管内皮生长因子受体对在体外诱导内皮祖细胞黏附、增殖和分化。血管内皮生长因子结合的支架和人工移植物引起EPC黏附和定植,随后在Porcein模型上内皮化。因此,我们的原型表面架构提出了在血液接触设备上提供非致敏潜力的新概念。
英文摘要
This study aims at in situ capture of endothelial progenitor cells (EPCs) on blood-contacting surfaces of cardiovascular devices in bloodstream. Among various cell surface receptor/legend pairs, only surface-bound VEGF/VEGF receptor pair induced adhesion, proliferation, and differentiation of EPCs in vitro. VEGF-bound stents and artificial grafts generated EPC adhesion and colonization, followed by endothelialization on porcein model. Thus, our prototype surface architecture to propose new concept of providing nonthrambogenic potential on blood-contacting devices.
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会议论文
Antibody-bound cell microarray for immunophenotyping: surface modification and lymphocyte subpopulations.
用于免疫表型分析的抗体结合细胞微阵列:表面修饰和淋巴细胞亚群。
DOI: 10.1002/jbm.b.31139
发表时间: 2008
期刊: Journal of biomedical materials research. Part B, Applied biomaterials
影响因子: --
作者: [Fujii,Yasuo, Anderson,JamesM, Matsuda,Takehisa]
通讯作者: Matsuda,Takehisa
Simultaneous Processing of Fibril Formation and Cross-Linking Improves Mechanical Properties of Collagen
原纤维形成和交联的同时处理可提高胶原蛋白的机械性能
DOI: --
发表时间: 2008
期刊: Biomacromolecules 9(3)
影响因子: --
作者: [S. Yunoki, T. Matsuda]
通讯作者: T. Matsuda
DOI: 10.1002/jbm.a.31660
发表时间: 2008-07
期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
影响因子: 4.9
作者: [Jones, Jacqueline A., Qin, L. Abby, Meyerson, Howard, Kwon, Il Keun, Matsuda, Takehisa, Anderson, James M.]
通讯作者: Anderson, James M.
International Review of Thrombosis
国际血栓形成综述
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [西村智, 長崎実佳]
通讯作者: 長崎実佳
共 15 条
    Toward Development of in-situ Endothelialized Artificial Graft : Hydrodynamic Shear Stress Dependent Retention of Endothelial Cells Adhered to a Vascular Endothelial Growth Factor-Fixed Surface
    • 批准号:
      18300165
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.93万
    • 财政年份:
      2006
    • 负责人:
      MATSUDA Takehisa
    • 依托单位:
    Mechanobiology in tissue formation and robotic engineering of functional tissues
    High-performance Stent Technology
    • 批准号:
      15200038
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $30.28万
    • 财政年份:
      2003
    • 负责人:
      MATSUDA Takehisa
    • 依托单位:
    Develop of High Performance Stents
    • 批准号:
      12358017
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $19.1万
    • 财政年份:
      2000
    • 负责人:
      MATSUDA Takehisa
    • 依托单位:
    海外基金