Relationship between VDR phenotype and sarcopenia with functional decline among the old-old Japanese people

本研究从横断面和纵向两个方面探讨了维生素D受体(VDR)基因表型与肌肉质量和肌力之间的关系，并探讨了VDR基因表型与肌肉量和肌力的关系。受试者为居住在东京都北部板桥区75岁及以上的老年人，为预防老年综合征和长期护理状态，邀请他们进行集体健康检查。在大规模健康体检中，测量肌肉力量，如握力和伸膝力，腰围作为骨量减少的指标，并测量TMIG能力指数作为功能能力的指标。结果，我们发现VDR表型与骨量减少有明显的关系。特别是VDR的Fok I，无论是从横断面还是纵向观察，都显示出老年人发生骨质疏松症进展和功能能力下降的显著风险，我们必须考虑这些基因表型和老年人的长期生活方式，以便在不久的将来预防骨质疏松症和功能衰退。

In the present study, the relationship between Vitamin D Receptor (VDR) gene phenotype and muscle mass and muscle strength as indicators of sarcopenia with functional decline were investigated among the elderly Japanese people living in the community from both cross-sectional and longitudinal aspects. The subjects, the old -old people with age 75 year-old and above living in the Itabashi Ward, northern part of Tokyo Metropolitan area, were invited to undertake mass health examination for prevention of geriatric syndrome and long-term care state. During mass health examination, they were measured muscle power such as grip strength and knee extension power, circumference of the girth as indicators of sarcopenia and also measured TMIG Index of Competence as an indicator of functional capacity.As a result, we found a clear relationship between VDR phenotype and sarcopenia with functional decline. Particularly, Fok I of VDR showed siginificant risk for progress of sarcopenia and decline of functional capacity among the old-old people from both cross-sectional and longitudinal observations.We have to consider these gene phenotype as well as long-term life style among the elderly in order to prevent sarcopenia and functional decline in near future.