Development of Combo Metal Catalysis for Rapid 1,3-Rearrangement of Propargyl Alcohols and Its Application to Efficient Transformations

我已经公开了MoO 2（acac）2、（Ph 3 P）AuCl和AgOTf的组合为炔丙醇的快速1，3-重排提供了强有力的催化体系。在大多数情况下，反应在室温下在1小时内进行，以优异的产率提供各种α，β-不饱和羰基化合物。在进一步研究其在不同底物中的应用时发现，在金催化下，含羰基、羟基或氨基的炔丙醇分子内环化反应，得到了3（2 H）-呋喃酮、呋喃和吡咯等杂环化合物。还合成了聚合物负载的阳离子金化合物，并显示出高的反应活性。通过简单过滤从反应混合物中定量回收，并重复使用四次。

I have disclosed that the combination of MoO2(acac)2, (Ph3P)AuCl, and AgOTf provides a powerful catalytic system for the rapid 1,3-rearrangement of propargyl alcohols. The reactions proceed at room temperature within 1 h in most cases to afford a variety of α,β-unsaturated carbonyl compounds in excellent yields. During the further study on its application to various substrates, it was found that the cationic gold-catalyzed intramolecular cyclizations of the propargyl alcohols having carbonyl, hydroxyl, or amino groups gave the heterocyclic compounds, such as 3(2H)-furanones, furanes, and pyrroles. A polymer-supported cationic gold compound was also synthesized and showed high reactivity. It was recovered quantitatively from the reaction mixture by simple filtration and reused for four runs.