The role of DCIR in the immune regulation

在这项研究中，DCIR不仅在关节炎的发生发展中起作用，而且在其他免疫相关疾病的发展中也起作用，如其他实验性自身免疫性疾病和变态反应性疾病。此外，我们还鉴定了DCIR的内源性碳水化合物配体，并表明该配体可以向DCIR输入抑制信号。在关节炎的病理分析中发现DCIR在骨代谢中的作用，发现DCIR不仅在DC中发挥作用，而且在破骨细胞和成骨细胞中也发挥作用。这些发现应该会支持免疫相关疾病的新疗法的开发。

In this study, it was revealed that DCIR functions not only the development of arthritis, but also the development of other immune-related diseases such as other experimental autoimmune and allergic diseases. Moreover, we identified an endogenous carbohydrate ligand for DCIR, and showed that the ligand can input inhibitory signal to DCIR. And the role of DCIR in the bone metabolism, which was discovered during the pathological analysis of arthritis, is also examined and found that DCIR functions not only in DCs, but also in osteoclasts and osteoblasts. These findings should support the development of new therapeutics for immune-related diseases.