Influence of histon deacetyrase inhibitor in induction of tumor-associated stroma in oral cancer cell line.

研究了组蛋白去乙酰化酶抑制剂之一丁酸钠（SB）对口腔癌细胞的作用。评估血管生成因子和淋巴管生成因子的RNA和蛋白表达水平。SB刺激下调血管生成素-2、血小板衍生生长因子β、VEGF-C、VEGF-D的表达水平。这些发现表明其在抗血管生成和淋巴管生成癌症治疗中的潜在应用。有趣的是，衰老因子VEGF-A和转录调节因子COX-2上调。现在，我们研究了机理的细节。

We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on oral cancer cells. RNA and protein expression level of angiogenic- and lymphangiogenic-factors are assessed. Expression level of angiopoietin-2, platelet derived growth factor beta, VEGF-C, VEGF-D are downregulated by SB stimulation. These findings indicating its potential use in anti-angiogenic and -lymphangiogenic cancer therapy. Interestingly, agiogenic factor VEGF-A and transcription regulator COX-2 are upregulated. Now, we investigated detail of the mechanism.