Functional analyses of DNA polymerases in nucleotide excision repair
Functional analyses of DNA polymerases in nucleotide excision repair
批准号:
20810021
负责人:
OGI Tomoo
金额:
$2.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (Start-up)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
关键词:
中文摘要
核苷酸切除修复(NER)从DNA中去除紫外线光渗漏。NER活性受损会导致色素性干皮病,这是一种皮肤癌易感性遗传病。NER的早期阶段已经确定,而涉及修复合成和缺口结扎的后期阶段还不是很清楚。在这里,我们证明了三种DNA聚合酶在NER修复合成中的协调作用。
英文摘要
Nucleotide excision repair (NER) removes the UV photolesions from DNA. Compromised NER activity causes xeroderma pigmentosum, a skin cancer predisposition genetic disorder. The early step of NER is well established, whereas the later step, which involves repair synthesis and nick ligasion, is not well understood. Here we demonstrate that three DNA polymerases coordinately role in the NER repair synthesis.
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DOI:
10.1093/nar/gkp023
发表时间:
2009-03
期刊:
Nucleic acids research
影响因子:
14.9
作者:
[Limsirichaikul S, Niimi A, Fawcett H, Lehmann A, Yamashita S, Ogi T]
通讯作者:
Ogi T
日本国特許
日本专利
DOI:
--
发表时间:
2006
期刊:
影响因子:
--
作者:
[]
通讯作者:
A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethyny1 deoxyuridine (EdU)
一种通过掺入乙炔脱氧尿苷 (EdU) 测量原代人成纤维细胞修复合成的快速非放射性技术
DOI:
--
发表时间:
2009
期刊:
Nucleic Acids Research 37
影响因子:
--
作者:
[Limsirichaikul, et al.]
通讯作者:
et al.
損傷DNA修復物質のスクリーニング方法
损伤DNA修复物质的筛选方法
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1016/j.molcel.2010.02.009
发表时间:
2010-03-12
期刊:
MOLECULAR CELL
影响因子:
16
作者:
[Ogi, Tomoo, Limsirichaikul, Siripan, Lehmann, Alan R.]
通讯作者:
Lehmann, Alan R.
共 7 条
Molecular pathogenesis of human genetic disorders associated with deficiency in the DNA repair and damage response system
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批准号:17H00783
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$27.37万
-
财政年份:2017
-
负责人:OGI Tomoo
-
依托单位:
Genetic diagnosis of microcephaly
-
批准号:16K15526
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
-
财政年份:2016
-
负责人:OGI Tomoo
-
依托单位:
Molecular epidemiology studies on rare genetic disorders and pediatric cancer cohorts associated with genome instability
-
批准号:15H02654
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$27.46万
-
财政年份:2015
-
负责人:OGI Tomoo
-
依托单位:
In vitro reconstitution of the initiation process of transcription-coupled nucleotide-excision repair
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批准号:26291005
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.65万
-
财政年份:2014
-
负责人:OGI Tomoo
-
依托单位:
A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents
-
批准号:24659533
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
-
负责人:OGI Tomoo
-
依托单位:
Stalled RNA polymerase processing in transcription-coupled nucleotide-excision repair
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批准号:24681008
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$17.8万
-
财政年份:2012
-
负责人:OGI Tomoo
-
依托单位:
Comprehensive analyses of the nucleotide excision repair (NER) molecular mechanisms
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批准号:22710056
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2010
-
负责人:OGI Tomoo
-
依托单位:
海外基金