Comparative pathological study on H5N1 infection between humans and animals

我们调查了H5N1感染的老虎和猫的尸检病例，这些动物食用了感染H5N1的新鲜鸡肉或死鸽子尸体，并因高热和严重的呼吸系统疾病而死亡。尸检时，感染动物的全身器官出现严重出血性病变。免疫组化法检测脑、肺、肝组织中H5N1相关抗原。此外，从受感染动物的肺组织中分离出一种病毒基因，该基因与从泰国一名人类患者中分离出的H5N1病毒高度相似。

We investigated autopsy cases of tigers and cats infected with H5N1.The animals had eaten fresh chicken or dead pigeon carcass infected with H5N1 and died caused by high fever and severe respiratory disorder. At necropsy, infected animals showed severe hemorrhagic lesion in a systemic organ. H5N1 related antigens was also detected in brain, lung and liver by an immunohistochemical method. Furthermore, a viral gene was isolated from lung tissue in infected animals and its showed high similarity to H5N1 isolated from a human patient in Thailand.