Studies on isolation, structure elucidation and asymmetric total syntheses of natural alkaloids towards the development of Alzheimer Disease

近年来，随着老年人数量的迅速增加，开发有效、安全的改善记忆力的药物成为当务之急。对乙酰胆碱酯酶（AChE）的抑制通过控制乙酰胆碱的功能使脑内乙酰胆碱含量增加，从而改善记忆缺陷。本研究旨在通过从石蒜科和苋菜科植物中分离，化学合成天然生物碱，寻找具有AChE抑制活性的生物碱（基础成分）。结果，我们成功地分离了许多新的生物碱，并实现了几种天然生物碱的全合成。

In recent years, by the rapid increase of the elderly person, development of effective and safe drugs for memory improvement becomes the urgent business. The inhibition of acetylcholine esterase (AChE) brings increase of acetylcholine in the brain by controlling a function of and can improve defects of memory.In this study, it was aimed for the search of alkaloids (base ingredient) which had AChE inhibitory activity by separation from Lycopodium and Amaryllidaceae plants, chemical synthesis of natural alkaloids. As a result, we succeeded in the isolation of many new alkaloids and achieved the total syntheses of several kinds of natural alkaloids.