A new strategy to conquer obesity by use of a newly discovered neuropeptide GALP

GALP被认为是一种调节摄食和能量代谢的神经肽，但没有关于GALP有效用于肥胖动物的报道。在本研究中，我们建立了GALP动物鼻内输注方法。我们研究了肥胖动物，如ob/ob， db/db和DIO小鼠，我们得到的数据表明，鼻内注射GALP对这些动物非常有效，可以减轻体重和减少食物摄入。提示在未来，鼻内输注GALP对肥胖者克服肥胖和生活方式相关疾病有帮助。

GALP is known as a neuropeptide whish regulates feeding and energy metabolism but there is no reports to use of GALP for obese animals efficiently. In this study, we have established the intranasal infusion method of GALP for animals. We have studied obese animals such as ob/ob, db/db and DIO mice and we got the data that intranasal infusion of GALP was very effective on these animals to loose body weight and food intake. It is suggested that intranasal infusion of GALP is useful for obese people to conquer obesity and life-style related diseases in future.