A novel treatment for liver injury by modulation oflipid mediator effects
A novel treatment for liver injury by modulation oflipid mediator effects
批准号:
22590716
负责人:
IKEDA Hitoshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
关键词:
中文摘要
门静脉高压症是肝硬化的重要并发症之一。我们已经成功地治疗门静脉高压症的啮齿动物模型抑制作用的鞘氨醇1-磷酸,脂质介质,其受体拮抗剂。由于我们的策略具有最小的副作用,如降低动脉压,其在人体中的应用应进一步研究。
英文摘要
Portal hypertension is well known as one of critical complications of liver cirrhosis. We have successfully treated portal hypertension in rodent models by inhibiting an effect of sphingosine 1-phosphate, a lipid mediator, with its receptor antagonist. Because our strategy had minimal side effects such as a reduction of arterial pressure, its application in human should be further examined.
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Liver involvement in sphingosine 1-phosphate dynamism revealed by adeniviral hepatic overexpression of apolipoprotein M.
载脂蛋白 M 的腺病毒肝脏过度表达揭示了肝脏参与 1-磷酸鞘氨醇动力学。
DOI:
--
发表时间:
2013
期刊:
Atherosclerosis
影响因子:
5.3
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y.]
通讯作者:
Yatomi Y.
門脈圧亢進症におけるスフィンゴシン1リン酸の関与
1-磷酸鞘氨醇与门脉高压的关系
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y., Takuwa Y, Kegeyama Y, 池田均, 池田均]
通讯作者:
池田均
受容体SIP2を介したスフィンゴシン1リン酸作用抑制による門脈圧亢進症治療の可能性
通过受体 SIP2 抑制 1-磷酸鞘氨醇作用来治疗门静脉高压症的可能性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y., Takuwa Y, Kegeyama Y, 池田均, 池田均, 池田均]
通讯作者:
池田均
リゾリン脂質と肝臓疾患
溶血磷脂与肝脏疾病
DOI:
--
发表时间:
2012
期刊:
臨床検査
影响因子:
--
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y., Takuwa Y, Kegeyama Y, 池田均]
通讯作者:
池田均
Elucidation of a role of sphingosine 1-phosphate on liver damage
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批准号:19590750
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2007
-
负责人:IKEDA Hitoshi
-
依托单位:
Elucidation of the clinical significance of autotaxin and lysophosphatidic acid in liver diseases.
-
批准号:17590618
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2005
-
负责人:IKEDA Hitoshi
-
依托单位:
Mechanisms of Hepatoblastoma Carcinogenesis in Low Birth Weight Infants
-
批准号:15591892
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2003
-
负责人:IKEDA Hitoshi
-
依托单位:
Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regeneration
-
批准号:14570451
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2002
-
负责人:IKEDA Hitoshi
-
依托单位:
-General Study of the Chinese Agriculture and Rural Economy after joining World Trade Organization-
-
批准号:14402031
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.62万
-
财政年份:2002
-
负责人:IKEDA Hitoshi
-
依托单位:
PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGY
-
批准号:12670461
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2000
-
负责人:IKEDA Hitoshi
-
依托单位:
Pathogenetic roles of human endogenous retroviruses in autoimmune diseases
-
批准号:12670193
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2000
-
负责人:IKEDA Hitoshi
-
依托单位:
ELUCIDATION OF SIGNIFICANCE OF c-met EXPRESSION IN ACTIVATED HEPATIC STELLATE GELLS AND ITS APPLICATION OF THERAPEUTIC STRATEGY
-
批准号:09670517
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:IKEDA Hitoshi
-
依托单位:
Mapping of the gene for Holmes' ataxia by searching of triplet repeats
-
批准号:09470057
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.65万
-
财政年份:1997
-
负责人:IKEDA Hitoshi
-
依托单位:
Platelet Epidermal Growth Factor and Liver Regeneration
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批准号:62570313
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1987
-
负责人:IKEDA Hitoshi
-
依托单位:
海外基金