Development of uveitis therapy with control for CD4+CD25+regulatory T cells

本研究的目的是阐明表达叶酸受体4（FR 4）的调节性T细胞（Treg）在实验性自身免疫性葡萄膜视网膜炎（EAU）中的作用和功能。由于在EAU小鼠中通过施用抗FR 4抗体来抑制T细胞增殖，EAU的严重程度倾向于增加。该结果表明，表达FR4的TcB具有抑制眼内炎症的作用。

The purpose of this investigation was to make clear the role and function of regulatory T cells(Treg) expressing folate receptor 4(FR4) which was recently known as a new marker of Tregs, on experimental autoimmune uveoretinitis(EAU) which is an animal model of human uveitis. As suppression of Tregs by administration of anti-FR4 antibody in EAU mouse, the severity of EAU tended to be increased. This result suggested that Tregs expressing FR4 had a role to suppress intraocular inflammations.