Surgical Therapy for the neuropathic pain.

以Beagle犬为研究对象，建立了神经性疼痛的动物实验模型。运用该模式，通过电生理、病理、生化等方法，对涉及局部和中枢神经系统的手术入路机制进行研究，揭示神经性疼痛发作的主要原因。我们在临床上已经发现，周围神经的局部恢复有助于减轻神经性疼痛，本研究揭示了这一机制的一部分。由于神经性疼痛的动物模型是通过周围神经结扎建立的，因此我们将其应用于Beagle犬坐骨神经作为神经性神经模型。对于新的治疗方法，我们挑战用PGA和胶原组成的神经导管代替受损部位，并评估周围修复是否有助于神经性疼痛的病理。

Animal experimental model was made in Beagle dogs on the neuropathic pain. Using this mode the mechanism was studied concerning the surgical approach which refers the local and central nerve systems with electrophysiological and pathological, biochemical methods to reveal the main reason of on-set of the neuropathic pain. We have already found in clinically that the local recovery of the peripheral nerve reads to reduce the neuropathic pain, the study revealed one part of this mechanism.Since the animal model of a neuropathic pain was established by ligation of the peripheral nerve, we applied it for the sciatic nerve of Beagle dogs as a model of the neuropathic nerve. For the new treatment, we challenged to replace the damaged site with a nerve conduit composed of PGA and collagen and evaluated nether peripheral repair may contribute the morbus of the neuropathic pain.