Differentiation of effector and tissue regulatory T cells

调节性T细胞(Tregs)几乎存在于人体的每个器官中，在预防炎症和维持健康方面发挥着核心作用。为了行使这些功能，特雷格经历了一个发育计划，细节鲜为人知。该项目将利用最新开发的生物工具和最先进的技术来揭示支配Treg发育和功能的分子机制。该项目将产生基本的科学知识和新的知识产权，为研究和开发提供新的机会。该项目的成果将有助于制定治疗自身免疫、癌症和代谢综合征等疾病的战略，从而使兽医和人类健康受益。

Regulatory T cells (Tregs) populate almost every organ of the body and play a central role in preventing inflammation and maintaining health. To exercise these functions, Tregs undergo a developmental program, the details of which are poorly known. This project will utilize newly developed biological tools and state-of-the-art technology to uncover the molecular mechanisms that govern Treg development and function. The project will generate basic scientific knowledge and new intellectual property that will afford new opportunities for research and development. The outcomes of this project will help to devise strategies to treat diseases such as autoimmunity, cancer and metabolic syndrome, and will thus benefit veterinary and human health.