Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

体育活动（PA）对健康和功能有许多深远的好处，但有有限的 这些益处背后的机械信号的知识。这些知识对于优化 有效使用PA作为特定疾病的预防或治疗干预策略， 人口。身体活动分子传感器联盟（MoTrPAC）的首要目标是 通过表征PA的分子反应来解决这一知识缺口。这将是完成 通过收集人类和动物的血液和组织样本， 进行了广泛的“组学”分析。通过生成一个全面的分子反应图， PA，MoTrPAC将为精确运动生物医学研究的新时代奠定基础 药科罗拉多大学安舒茨医学院（CU-AMC）非常有准备， 领导MoTrPAC成人临床中心，并为所有联盟活动做出贡献。我们的调查人员和 合作者在复杂的临床PA干预试验方面具有丰富的经验，包括组织取样， 在整个成年年龄段的人群中。我们的专业知识涵盖多个生理 系统，疾病和健康状况，并包括广泛的生理，代谢和 形态测定表型CU-AMC用于MoTrPAC活动的设施非常出色。拟议 MoTrPAC -科罗拉多临床中心将实现以下特定目标（SA）： 战略领域1：促进并在适当情况下领导以下文件所述的所有交通和公共工程部第1阶段规划活动（第1年） RFA-RM-15-015，通过参加MoTrPAC指导委员会和小组委员会。地方目标 阶段1的任务是完成任务（例如，获得监管部门的批准，培训员工），使第2阶段能够 从第二年开始。 SA 2：在CU-AMC招募并入组450名成人（或第1阶段确定的人数），进行急性 根据联合体制定的协议进行PA测试和PA干预，并执行所有其他 MoTrPAC第2阶段活动（第2至5年）。高度熟练的临床研究人员将领导七个 “团队”将负责：招募，筛选和保留;生理，代谢， 形态测定表型;生物标本采集;生物标本处理;急性PA试验;慢性PA 干预措施;以及数据管理和质量保证。 SA 3：随着动物和人类数据从化学分析中心和生物信息学中获得 中心，我们将参与所有第三阶段的活动，包括数据分析，手稿准备， 传播成果。这些活动将由交通和公共行政部指导委员会指导， 小组委员会。在地方一级，我们将每年举办一次为期一天的关于PA、健康和健身的地方研讨会 促进CU-AMC和MoTrPAC附近其他学术机构的研究人员的兴趣。

Physical activity (PA) has numerous and profound benefits on health and function, yet there is limited knowledge of the mechanistic signals that underlie these benefits. Such knowledge is critical for optimizing the effective use of PA as a preventive or therapeutic intervention strategy for specific diseases and in specific populations. The overarching goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to address this knowledge gap by characterizing the molecular responses to PA. This will be accomplished through the collection of blood and tissue samples from both humans and animals, which will then be subjected to extensive “Omics” analyses. By generating a comprehensive map of molecular responses to PA, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. The University of Colorado Anschutz Medical Campus (CU-AMC) is exceptionally well poised to lead a MoTrPAC Adult Clinical Center and to contribute to all Consortium activities. Our investigators and collaborators have extensive experience with complex clinical PA intervention trials, including tissue sampling, in cohorts spanning the entire adult age spectrum. Our expertise extends across multiple physiological systems, diseases, and health conditions, and includes broad proficiency in physiologic, metabolic, and morphometric phenotyping. The facilities at CU-AMC for MoTrPAC activities are outstanding. The proposed MoTrPAC – Colorado Clinical Center will accomplish the following Specific Aims (SA): SA1: Contribute to, and lead when appropriate, all MoTrPAC Phase 1 planning activities (Year 1) described in RFA-RM-15-015 through participation on the MoTrPAC Steering Committee and Subcomittees. The local goals for Phase 1 will be to accomplish tasks (e.g., obtain regulatory approvals, train staff) that will enable Phase 2 to start at the beginning of Year 2. SA2: Recruit and enroll 450 adults at CU-AMC (or the number determined during Phase 1), conduct the acute PA tests and PA intervention according to protocols established by the Consortium, and carry out all other MoTrPAC Phase 2 activities (Years 2 to 5). Highly accomplished clinical investigators will lead the seven “teams” that will be responsible for: recruitment, screening, and retention; physiologic, metabolic, and morphometric phenotyping; biospecimen acquisition; biospecimen processing; acute PA tests; chronic PA interventions; and data management and quality assurance. SA3: As animal and human data become available from the Chemical Analysis Sites and Bioinformatics Center, we will participate in all Phase 3 activities, including data analysis, preparation of manuscripts, and dissemination of results. These activities will be guided by the MoTrPAC Steering Committee and Subcommittees. On the local level, we will host an annual 1-day local symposium on PA, Health, and Fitness to catalyze the interest of investigators at CU-AMC and other nearby academic institutions in MoTrPAC.