Longevity and Stress in African American Families

这项应用的目的是确定感知压力的模式，积极应对方式，健康状况 以及在非裔美国人家庭中观察到的有助于长寿的基因。我们将研究这些 通过研究兄弟姐妹和亲子之间的相似性，使用纵向和横向方法研究影响因素 对.为此，我们有以下问题： 1)家庭效应（基因和共享环境）是否会在感知的模式中产生相似性？ 压力和应对内和跨代？ 2)压力能解释不同家庭之间寿命模式的差异吗？ 3)心理社会因素，如压力，应对和歧视，解释了不同的模式， 健康状况和寿命之间的关系？ 4)基因在压力和长寿模式中扮演什么角色？ 5)与压力和长寿相关的基因之间是否存在基因-环境相互作用， 环境因素，如家庭经济困难和歧视？ 为了解决这些研究问题，我们计划了五个具体目标： 1)收集750名老年非裔美国人对压力、歧视、应对 多代家庭（父母-子女和兄弟姐妹）的风格、健康、个性和遗传。 2)检查兄弟姐妹之间在压力和应对以及健康状况方面的相似性和差异 在家庭中代代相传。 3)比较压力大、应对差的同胞与压力大、应对差的同胞的健康状况， 压力更小应对能力更强 4)在长寿家庭的比较中检查与压力和长寿相关的基因， 短命的家庭和兄弟姐妹之间。 5)在与压力和长寿相关的基因之间是否存在基因-环境相互作用 以及家庭经济困难和歧视等环境因素？ 这个项目是新颖和创新的，它将采用多种方法来理解 中心blog它将使用定量遗传学方法、分子遗传学方法和多基因遗传学方法。 生成方法。据我们所知，这是第一次采用所有这些方法 一个样本。

The goal of this application is to identify patterns of perceived stress, active coping style, health status and genes that contribute to longevity observed within African American families. We will examine these factors using vertical and horizontal approaches by studying similarities between siblings and parent-child pairs. To this end, we have the following questions: 1) Do familial effects (genes and shared environments) create similarity in the patterns of perceived stress and coping within and across generations? 2) Does stress account for differences in patterns of longevity between families? 3) Do psychosocial factors like stress, coping, and discrimination account for differences in patterns of health status and longevity between families? 4) What role do genes play in patterns of stress and longevity? 5) Are there gene-environment interactions between genes associated with stress and longevity and environmental factors such as family financial adversity and discrimination? To address these research questions, we have planned five specific aims: 1) Collect data from 750 older African Americans on perceptions of stress, discrimination, coping style, health, personality and genetics from multi-generation families (parent-child and siblings). 2) Examine similarities and differences in stress and coping, and health status among sibling pairs and across generations within families. 3) Compare the health status of siblings concordant for higher stress and poorer coping to those with lower stress and better coping. 4) Examine genes associated with stress and longevity in comparisons of long lived families and short lived families and among sibling pairs. 5) Are there gene-environment interactions between genes associated with stress and longevity and environmental factors such as family financial adversity and discrimination? This project is novel and innovative in that it will employ a multi method approach to understand longevity. It will use a quantitative genetic approach, a molecular genetic approach, and a multi generation approach. To our knowledge, this is the first time all of these methods have been employed on one sample.