Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology

项目摘要 这个T32提案将建立一个创新的跨学科博士后培训计划，重点是 精神病理学的transdiagnosis，神经发育机制，扩大重点 发展和环境的影响-程序标题：西北大学心理健康，早期： 神经发育机制的跨诊断、跨学科、转化训练计划 精神病理学（NU-MHE）精神病理学的可塑性神经发育机制. 关键的发展拐点已被证明是难以捉摸的，这表明创新的方法和框架， 这是必要的，以促进干预和预防工作。NIMH的研究领域 标准（RDoC）倡议，框架精神障碍作为神经发育现象，出现在一个 从脆弱性到临床病理学的演变过程。这导致了新的研究化学， 从传统的、离散的基于疾病的模型转向更多层次的设计， 跨诊断，跨学科的方法。然而，该领域缺乏有效的培训模式， 捕捉这种动态的、多面的自然。因此，T32提出了一种新颖的训练范式， 高翻译邻近区精神障碍的神经发育机制研究 意义研究员将发展精神病理学神经发育机制的专业知识，考虑到 考虑到发展和环境背景。此外，研究员将获得以下方面的基础知识： 以下核心能力：（1）计算精神病学和其他数据科学应用于心理 健康，（2）干预/预防/实施科学，（3）心理健康和儿科的交叉 身体条件-以及以下专业发展能力，（4）翻译团队 科学，（5）临床研究的道德和负责任的行为（包括关注多样性），（6） 资助，支持K或R级资助提交，以及（7）领导力和其他职业发展 skills.为了实现这些能力，至少85%的研究员的时间将花在指导独立 research.所有研究员将有两名共同导师：一名具有神经发育机制专业知识的共同导师 （a）预防、干预或治疗; 实施，（B）计算精神病学和数据科学，或（c）精神和儿科的交叉 健康这些研究经验将通过神经发育机制的研讨会得到补充， 精神病理学，数据科学/计算精神病学，以及经验学习（例如，的研究 真实的世界护理的背景）。研究员还将利用NU丰富的教育资源，包括 专业发展培训，在赠款写作，团队科学技能，指导他人，严谨性和可重复性， 以及其他用于职业发展的资源。NU-MHE已准备好推出下一代 神经发育临床科学家和领导者准备加快临床转化的步伐。

Project Summary This T32 proposal will establish an innovative transdisciplinary postdoctoral training program focusing on transdiagnostic, neurodevelopmental mechanisms of psychopathology, with an expanded focus on developmental and environmental influences - program title: Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology (NU-MHE). Specifying malleable neurodevelopmental mechanisms of psychopathology at key developmental inflection points has proven elusive, suggesting that innovative methods and frameworks are necessary in order to advance intervention and prevention efforts. Approaches like NIMH’s Research Domain Criteria (RDoC) initiative, frame mental disorders as neurodevelopmental phenomena which emerge during an unfolding sequence from vulnerability to clinical symptomatology. This has led to novel research heuristics and designs which move away from conventional, discrete disease-based models towards more multi-level, transdiagnostic, transdisciplinary, approaches. However, the field is lacking training paradigms that effectively capture this dynamic, multi-faceted nature. This T32 thus proposes a novel training paradigm that bridges research in neurodevelopmental mechanisms of mental disorder with adjacent domains of high translational significance. Fellows will develop expertise in neurodevelopmental mechanisms of psychopathology, taking into account developmental and environmental contexts. Additionally, fellows will acquire foundational knowledge in the following core competencies: (1) computational psychiatry and other data science applications to mental health, (2) intervention/prevention/implementation science, (3) intersection of mental health and pediatric physical conditions – as well as the following professional development competencies, (4) translational team science, (5) ethical and responsible conduct of clinical research (which includes attentiveness to diversity), (6) grantsmanship, supporting a K or R-level grant submission, and (7) leadership and other career development skills. To achieve these competencies, at least 85% of the fellows’ time will be spent in mentored independent research. All fellows will have two co-mentors: A co-mentor with expertise in neurodevelopmental mechanisms of psychopathology; and a co-mentor in one of the following areas: (a) prevention, intervention, or implementation, (b) computational psychiatry and data science, or (c) the intersection of mental and pediatric health. These research experiences will be complemented by seminars in neurodevelopmental mechanisms of psychopathology, data science/computational psychiatry, as well as experiential learning (e.g., research in the context of real world care). Fellows will also make use of the rich educational resources available at NU, including professional development training in grant writing, team science skills, mentoring others, rigor and reproducibility, and other resources dedicated to career development. NU-MHE is well-positioned to launch the next generation of neurodevelopmental clinical scientists and leaders poised to accelerate the pace of clinical translation.