Training in Cardiovascular Translational Research

项目摘要/摘要 这项申请要求继续为博士后(6个名额，增加2个名额)和博士后 博士学位(4个名额，保持不变)培训补助金，题为‘心血管翻译培训 “研究”。我们的目标是培养未来的简历科学家，他们拥有从 通过开发新的治疗方法将实验室转化为临床实践。关键的创新是 这门课程涵盖了成功的治疗发现、验证和 发展包括：1)心血管疾病/靶标识别的基本机制；2)靶标/高剂量下药 吞吐量筛选；3)使用人类疾病的相关动物模型进行目标验证/概念验证； 4)药物化学导论。化合物/生物制品的优化。5)基本概念 知识产权保护；6)医学药理学基础；6)毒理学基础；7) 从临床前到IND备案的药物开发原理；8)临床试验基础。一种新的 这一非常成功的计划的维度侧重于基于结构的心血管药物发现。 教师导师指导四个主要领域的研究培训：1)简历信号的结构生物学 分子，包括解决离子通道和G蛋白偶联受体的结构；2)CV的生物物理 细胞信号转导，包括离子通道、心肌和平滑肌信号转导；3)心血管动物模型 疾病，包括心力衰竭、心律失常、动脉粥样硬化和糖尿病的小鼠模型；以及4) 临床-翻译CV科学，包括人类干细胞的综合使用，心血管遗传学 疾病、生物材料支架和生物反应器、临床电生理学和心力衰竭。另一个 创新为接触临床的博士后和博士后实习生提供临床接触/培训 在心脏病研究员的监督下在医院开展活动，以获得对 他们的基础研究与人类心血管疾病的相关性。学员申请独立资助继续 他们的培训经过了两年的赠款支持。博士前候选人是从一个庞大而多样的 哥伦比亚大学医学中心─细胞7个研究生项目的优秀申请者池 生理学与生物物理学、生物化学与分子生物物理学、病理学与细胞生物学、 综合计划，营养和代谢生物学，药理学和分子信号。博士后 候选人是从庞大的直接申请者库中挑选出来的，直接为教职员工提供课程。持续的努力 招募妇女和少数民族的工作继续取得成功。培训计划为心血管疾病提供 系列研讨会、期刊俱乐部、联合实验室会议和务虚会，促进合作和 跨学科研究。该计划利用了哥伦比亚大学的许多现有优势 大学，包括欧文临床和翻译研究中心(CTSA)，梅尔曼学院 公共卫生、基因组中心、生物信息学、组织和生物医学工程。

Project Summary/Abstract This application requests continued funding for a pre-doctoral (6 slots, an increase of 2 slots) and post- doctoral (4 slots, remains the same) training grant entitled, `Training in Cardiovascular Translational Research'. The goal is to train future CV scientists who have expertise in bringing basic discoveries from the laboratory into clinical practice through development of novel therapeutics. The KEY INNOVATION is a course covering the major disciplines required for successful therapeutics discovery, validation and development including: 1) basic mechanisms in CV diseases/target identification; 2) drugging the target/high throughput screening; 3) target validation/proof of concept using relevant animal models of human disease; 4) introduction to medicinal chemistry – optimization of compounds/biologicals; 5) basic concepts of intellectual property protection; 6) fundamentals of medical pharmacology; 6) basics in toxicology; 7) principals of drug development from pre-clinical to IND filing; 8) fundamentals of clinical testing. A new dimension to this highly successful program focuses on structure-based cardiovascular drug discovery. Faculty mentors direct research training in four primary areas: 1) Structural Biology of CV Signaling Molecules, including solving structures of ion channels and G-protein coupled receptors; 2) Biophysics of CV Cell Signaling, including ion channels, cardiac and smooth muscle signaling; 3) Animal Models of CV Diseases, including mice models of heart failure, cardiac arrhythmias, atherosclerosis, and diabetes; and 4) Clinical-Translational CV Sciences, including integrated use of human stem cells, genetics of cardiovascular diseases, biomaterial scaffolds and bioreactors, clinical electrophysiology, and heart failure. Another innovation provides clinical exposure/training for pre- and postdoctoral trainees who are introduced to clinical activities in the hospital under the supervision of cardiology fellows in order to gain appreciation of the relevance of their basic research to human CV disease. Trainees apply for independent funding to continue their training after two years of grant support. Pre-doctoral candidates are selected from a large and diverse pool of outstanding applicants to 7 graduate programs at Columbia University Medical Center─ Cellular Physiology and Biophysics, Biochemistry and Molecular Biophysics, Pathology and Cell Biology, the Integrated Program, Nutritional and Metabolic Biology, Pharmacology and Molecular Signaling. Post-doctoral candidates are selected from a large applicant pool of direct applicants to program faculty. Ongoing efforts to recruit of woman and minorities continue to be successful. The training program provides cardiovascular seminar series, journal clubs, joint laboratory meetings and retreats that foster collaborations and interdisciplinary research. The program takes advantage of the many existing strengths of Columbia University, including the Irving Center for Clinical and Translational Research (CTSA), Mailman School of Public Health, Genome Center, Bioinformatics, and Tissue and Biomedical Engineering.